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NMR Applications in Biopolymers

  • J. W. Finley
  • S. J. Schmidt
  • A. S. Serianni

Part of the Basic Life Sciences book series (BLSC, volume 56)

Table of contents

  1. Front Matter
    Pages i-x
  2. S. J. Schmidt, A. S. Serianni, J. W. Finley
    Pages 1-6
  3. Niels H. Andersen, Xiaonian Lai, Philip K. Hammen, Thomas M. Marschner
    Pages 95-134
  4. Thomas L. James, Brandan A. Borgias, Anna Maria Bianucci, Ning Zhou
    Pages 135-154
  5. J. M. V. Blanshard, E. M. Jaroszkiewicz, M. J. Gidley
    Pages 155-173
  6. Helmut Pessen, Thomas F. Kumosinski, Harold M. Farrell Jr.
    Pages 175-197
  7. Lawrence J. Berliner, Robert Kaptein, Keiko Koga, Giovanni Musci
    Pages 231-253
  8. Robert G. Bryant, S. D. Kennedy, C. L. Jackson, Thomas M. Eads, William R. Croasmun, Allen E. Blaurock
    Pages 255-271
  9. Natsuko Cyr, R. M. Elofson, G. W. Mathison
    Pages 287-302
  10. Harold C. Jarrell, Ian C. P. Smith
    Pages 303-316
  11. Robert E. London, Scott A. Gabel, Michael E. Perlman
    Pages 349-360
  12. D. André d’Avignon, Chi-Cheng Hung, Mark T. L. Pagel, Bradley Hart, G. Larry Bretthorst, Joseph J. H. Ackerman
    Pages 391-414
  13. Shelly J. Richardson Schmidt
    Pages 415-459
  14. D. Sobczynska, C. Setser, H. Lim, L. Hansen, J. Paukstelis
    Pages 461-480
  15. Back Matter
    Pages 511-515

About this book

Introduction

Elucidating the structures of biopolymers as they exist in nature has long been a goal of biochemists and biologists. Understanding how these substances interact with themselves, other solutes, and solvents can provide useful insights into many areas of biochemistry, agriculture, food science and medicine. Knowledge of the structure of a protein or complex carbohydrate in its native form provides guidelines for the chemical or genetic modifications often desired to optimize these compounds to specific needs and applications. For example, in the pharmaceutical industry, structure-function relationships involving biopolymers are studied rou­ tinely as a means to design new drugs and improve their efficacies. The tools to conduct structure investigations of biopolymers at the molecular level are limited in number. Historically X-ray crystallography has been the most attractive method to conduct studies of this type. How­ ever, X-ray methods can only be applied to highly ordered, crystalline materials, thus obviating studies of solution dynamics that are often critical to attaining a global understanding of biopolymer behavior. In recent years, nuclear magnetic resonance (NMR) spectroscopy has evolved to become a powerful tool to probe the structures of biopolymers in solution and in the solid state. NMR provides a means to study the dynamics of polymers in solution, and to examine the effects of solute, solvent and' other factors~n polymer behavior. With the development of 2D and 3D forms of NMR spectroscopy, it is now possible to assess the solution conforma­ tions of small proteins, oligonucleotides and oligosaccharides.

Keywords

Nucleotide Oligosaccharid Oligosaccharide biochemistry chemistry crystallography food genetic modification pharmaceutical protein proteins spectroscopy structure

Editors and affiliations

  • J. W. Finley
    • 1
  • S. J. Schmidt
    • 2
  • A. S. Serianni
    • 3
  1. 1.Nabisco Brands, Inc.East HanoverUSA
  2. 2.University of IllinoisUrbanaUSA
  3. 3.University of Notre DameNotre DameUSA

Bibliographic information