Antioxidants in Therapy and Preventive Medicine

1. Antioxidant Vitamins

   1. The Role of Oxidative Modification and Antioxidants in LDL Metabolism and Atherosclerosis

      • Wendy Jessup, Roger T. Dean, Catherine V. de Whalley, Sara M. Rankin, David S. Leake

      Pages 139-142

   2. Effects of Vitamin E Treatment in Cholestatic Children

      • Frédérique Lemonnier, Fernando Alvarez, François Babin, Martine Couturier, Daniel Alagille

      Pages 143-146

   3. Efficacy of Vitamin E as a Drug in Inflammatory Joint Diseases

      • K. H. Schmidt, W. Bayer

      Pages 147-150

   4. Vitamin E and Correlated Antioxidants: A γ Radiolysis Study

      • D. Jore, M. N. Kaouadji, C. Ferradini

      Pages 151-154

   5. Ascorbate: The Most Effective Antioxidant in Human Blood Plasma

      • Balz Frei, Roland Stocker, Laura England, Bruce N. Ames

      Pages 155-163

2. Other Natural and Synthetic Antioxidants

   1. Radical Chemistry of Flavonoid Antioxidants

      • Wolf Bors, Werner Heller, Christa Michel, Manfred Saran

      Pages 165-170

   2. Scavenging Effects of Aspalathus Linealis (Rooibos Tea) on Active Oxygen Species

      • T. Yoshikawa, Y. Naito, H. Oyamada, S. Ueda, T. Tanigawa, T. Takemura et al.

      Pages 171-174

   3. Selenium and Oxidant Injury in Patients with Cystic Fibrosis

      • M. J. Richard, B. Aguilaniu, J. Arnaud, J. P. Gout, A. Favier

      Pages 175-178

   4. Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts: Their Effects Against H2O2 or UVB Induced Toxicity

      • M. J. Richard, P. Frappat, J. Arnaud, A. Favier

      Pages 179-182

   5. Selenium Therapy in Down Syndrome (DS): A Theory and a Clinical Trial

      • Erkki Antila, Ulla-Riitta Nordberg, Eeva-Liisa Syväoja, Tuomas Westermarck

      Pages 183-186

   6. Protection by Seleno-Organic Compound, Ebselen, Against Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

      • S. Ueda, T. Yoshikawa, S. Takahashi, Y. Naito, H. Oyamada, T. Takemura et al.

      Pages 187-191

   7. Biological Activities and Clinical Potential of Ebselen

      • Michael J. Parnham

      Pages 193-197

   8. Glutathione Level in Mice Brain After Testosterone Administration

      • Faik Atroshi, Lars Paulin, Tiina Paalanen, Tuomas Westermarck

      Pages 199-202

   9. Prostaglandins, Glutathione Metabolism, and Lipid Peroxidation in Relation to Inflammation in Bovine Mastitis

      • Faik Atroshi, Satu Sankari, Aldo Rizzo, Tuomas Westermarck, Jouko Parantainen

      Pages 203-207

   10. Sulfur Containing Compounds as Antioxidants

       • Patrick M. Dansette, Amor Sassi, Colette Deschamps, Daniel Mansuy

       Pages 209-215

   11. Zinc — a Redox-Inactive Metal Provides a Novel Approach for Protection Against Metal-Mediated Free Radical Induced Injury: Study of Paraquat Toxicity in E. Coli

       • Mordechai Chevion, Pnina Korbashi, Joshua Katzhandler, Paul Saltman

       Pages 217-222

   12. Antioxidative Action of Zinc-Carnosine Compound Z-103

       • T. Tanigawa, T. Yoshikawa, Y. Naito, T. Yoneta, S. Ueda, H. Oyamada et al.

       Pages 223-228

   13. High Molecular Weight Forms of Deferoxamine: Novel Therapeutic Agents for Treatment of Iron-Mediated Tissue Injury

       • Bo E. Hedlund, Philip E. Hallaway, John R. Mahoney

       Pages 229-234

   14. Oxygen Toxicity: Role of Hydrogen Peroxide and Iron

       • B. S. van Asbeck

       Pages 235-246

   15. Antioxidant Properties of an Antiischaemic Agent : Trimetazidine

       • Pascale Clauser, Catherine Harpey

       Pages 247-250

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.

• antioxidant
• biology
• enzyme
• enzymes
• preventive medicine
• research
• toxicity
• Ultrasonography

• Centre National de la Recherche Scientifique, University of Paris, Paris, France

  Ingrid Emerit

• Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, Paris, France

  Ingrid Emerit

• Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, USA

  Lester Packer

• Institut Gustave-Roussy, Villejuif, France

  Christian Auclair

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