Cerebral Blood Flow

1. Front Matter

   Pages i-viii

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2. Mathematical Models

   1. Front Matter

      Pages 1-1

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   2. Stochastic Models and Linear Tracer Kinetics

      • Aldo Rescigno

      Pages 3-18

   3. On Modeling Flow Data using Generalized Stochastic Compartmental Models

      • J. H. Matis, K. B. Gerald

      Pages 19-33

3. Autoradiography

   1. Front Matter

      Pages N3-N3

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   2. Basic Principles in Imaging of Regional Cerebral Metabolic Rates with Radioisotopes

      • Louis Sokoloff

      Pages 35-65

   3. Multi-Tracer Autoradiography for the Simultaneous Measurement of Cerebral Blood Flow and Metabolism

      • Günter Mies

      Pages 67-90

4. Single Photon Emission Tomography

   1. Front Matter

      Pages 91-91

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   2. Introduction to Methods Used for Measuring Regional Cerebral Blood Flow with Single Photon Emission Tomography

      • Giovanni Lucignani, Maria Carla Gilardi

      Pages 93-106

   3. Estimating Blood Flow by Deconvolution of the Injection of Radioisotope Tracers

      • Andrew Todd-Pokropek

      Pages 107-119

   4. Regional Cerebral Blood Flow Measurements Using the 133-Xenon Inhalation Method

      • G. Rodriguez, F. De Carli, G. Novellone, S. Marenco, G. Rosadini

      Pages 121-143

5. Positron Emission Tomography

   1. Front Matter

      Pages N7-N7

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   2. An Introduction to the Physics and Instrumentation of Positron Emission Tomography

      • G. W. Bennett

      Pages 145-164

6. Nuclear Magnetic Resonance

   1. Front Matter

      Pages N9-N9

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   2. Nuclear Magnetic Resonance (NMR) Spectroscopy: Basic Principles and Some Applications to Studies of Cerebral Metabolism

      • J. Feeney

      Pages 165-183

   3. Nuclear Magnetic Resonance Imaging

      • Laurance D. Hall, Steven C. R. Williams

      Pages 185-199

   4. Measurement and Interpretation of T1 and T2

      • C. A. Boicelli, A. M. Baldassarri, A. M. Giuliani, M. Giomini

      Pages 201-213

   5. Flow Studies

      • Edgar Müller

      Pages 215-243

   6. Perfusion Studies and Fast Imaging

      • R. Turner

      Pages 245-258

7. Back Matter

   Pages 259-263

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The NATO Advanced Study Institute on "Cerebral Blood Flow: Mathematical Models, Instrumentation, and Imaging Techniques" was held in L'Aquila, Italy, June 2-13, 1986. Contributions to this program were received from the University of L'Aquila, Consiglio Nazionale delle Ricerche, Siemens Elettra S.p.A., and Bracco S.p.A. Recent studies of the cerebral blood circulation have lagged behind analysis of other parameters such as glucose utilization, transmitter distribution, and precursors. This Advanced Study Institute tried to fill this gap by analyzing in detail different physical techniques such as Autoradiography (including Double-Tracer Auto­ radiography and highly specific tracers as Iodoantipyrine, Micro­ spheres), Single Photon Emission Computed Tomography, Nuclear Magnetic Resonance. Each method was analyzed in regards to its precision, resolution, response time. A considerable part of this Institute was devoted to the mathematics of CBF measurement, in its two aspects, i.e. the modeling of the underlying kinetic system and the statistical analysis of the data. The modeling methods proposed included the development of a differential algebra whereby the differential and integral equations involved could be solved by simple algebraic methods, including graph­ theoretical ones; the statistical methods proposed included the illustration of different parametrizations of possible use in the interpretation of experimental results.

• blood
• circulation
• computed tomography
• computed tomography (CT)
• development
• distribution
• imaging
• imaging techniques
• instrumentation
• magnetic resonance
• metabolism
• nuclear magnetic resonance (NMR)
• radiography
• tomography

• Institute of Experimental and Clinical Medicine, University of Ancona, Ancona, Italy

  Aldo Rescigno

• NMR Laboratory, IRCCS San Raffaele, Milano, Italy

  Andrea Boicelli

Policies and ethics