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Cellular and Molecular Aspects of Inflammation

  • George Poste
  • Stanley T. Crooke

Part of the New Horizons in Therapeutics book series (NHTH)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Cellular Interactions in Inflammatory Processes

    1. Front Matter
      Pages 1-1
    2. T. D. Geppert, P. E. Lipsky
      Pages 3-29
    3. Kathleen A. Haines, Joan Reibman, Gerald Weissmann
      Pages 31-40
    4. Myron I. Cybulsky, M. K. William Chan, Henry Z. Movat
      Pages 41-56
    5. Morris Ziff, Druie Cavender
      Pages 57-64
  3. Peptide Mediators of Inflammation

    1. Front Matter
      Pages 65-65
    2. Stephen M. Krane
      Pages 67-73
    3. Steven B. Mizel
      Pages 75-95
    4. Kirk R. Manogue, Anthony Cerami
      Pages 123-150
  4. Biosynthesis and Release of Lipid Mediators of Inflammation

    1. Front Matter
      Pages 151-151
    2. Stephen M. Spaethe, Philip Needleman
      Pages 153-169
    3. Joshua Rokach, Brian J. Fitzsimmons
      Pages 171-206
  5. Molecular Intermediates in Signal Transductions

    1. Front Matter
      Pages 207-207
    2. John H. Exton
      Pages 229-263
    3. Robert M. Bell, Carson R. Loomis, Yusuf A. Hannun
      Pages 265-286
  6. Receptors and Signal Transduction Processes Involved in Inflammation

    1. Front Matter
      Pages 303-303
    2. Catherine H. Koo, Laurent Baud, Jeffrey W. Sherman, Jeanne P. Harvey, Daniel W. Goldman, Edward J. Goetzl
      Pages 305-319
    3. Stanley T. Crooke, Seymour Mong, Mike Clark, Henry Sarau, Angela Wong, Raju Vegesna et al.
      Pages 321-334
    4. Perry V. Halushka, Dale E. Mais, David L. Saussy Jr.
      Pages 335-354
    5. Ronald J. Uhing, Susan B. Dillon, Paul G. Polakis, Artis P. Truett III, Ralph Snyderman
      Pages 355-379
  7. The Role of Phospholipases in Inflammation

    1. Front Matter
      Pages 403-403
    2. Pedro Cuatrecasas
      Pages 405-412
    3. Edward A. Dennis, Florence E. Davidson, Raymond A. Deems
      Pages 413-426
    4. Philip W. Majerus, Thomas M. Connolly, Vinay S. Bansal, Roger C. Inhorn, Hans Deckmyn
      Pages 443-458
  8. Back Matter
    Pages 459-469

About this book

Introduction

The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de­ fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter­ cellular transmitters, the receptors, signal transduction processes and regula­ tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho­ cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re­ sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho­ lipid components of the membranes is emphasized by recent studies.

Keywords

Lipid immune system inflammation molecular aspects receptor

Editors and affiliations

  • George Poste
    • 1
  • Stanley T. Crooke
    • 1
  1. 1.Department of Molecular PharmacologySmith Kline & French LaboratoriesPhiladelphiaUSA

Bibliographic information