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Radiation Carcinogenesis and DNA Alterations

  • Book
  • © 1986

Overview

Editors:
  1. F. J. Burns

    1. New York University Medical Center, New York, USA

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  2. A. C. Upton

    1. New York University Medical Center, New York, USA

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  3. G. Silini

    1. U.N. Scientific Committee on the Effects of Atomic Radiation, Vienna, Austria

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Part of the book series: NATO Science Series A: (NSSA, volume 124)

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Table of contents (50 chapters)

  1. DNA Strand Breaks and Chromosome Alterations

    1. Chemical Inhibition of the Repair of DNA Single Strand Breaks Produced by X-irradiation or Hydrogen Peroxide in Cultured Mammalian Cells

      • O. Cantoni, F. Cattabeni
      Pages 297-304

    2. Conjugated Dienes and TBA Reactive Material as Components of Chromosome Breakage Factors

      • S. H. Khan, I. Emerit
      Pages 305-311

    3. Conversion of Covalently Closed Circular DNA into Circular and Linear DNA by Ionizing Radiation in the Presence and Absence of DNA-binding or Intercalating Drugs

      • P. Ohneseit, W. Kohnlein
      Pages 313-319

    4. How Soon After Irradiation Do Chromosome Aberrations Form and Become Irreversible: a Direct Analysis by Means of the Premature Chromosome Condensation Technique

      • G. E. Pantelias, J. K. Wiencke, V. Afzal
      Pages 321-329

    5. Production by Radiation of DNA Double Strand Breaks in Three Mammalian Cell Lines and their Repair in Foetal Human Fibroblasts

      • O. Sapora, A. Maggi, M. Quintiliani
      Pages 331-337

  2. Mutations and Gene Expression

    1. The Role of Oncogenes in Multistage Carcinogenesis

      • K. Brown, M. Quintanilla, M. Ramsden, A. Balmain
      Pages 339-351

    2. A Regulatory Sequence of Simian Virus 40 is Inactivated by UV-Induced Damage

      • T. C. Brown, P. A. Cerutti
      Pages 353-357

    3. Mechanisms of Spontaneous Mutagenesis: Implications for Spontaneous Carcinogenesis

      • Kendric C. Smith, Neil J. Sargentini
      Pages 359-371

    4. A Method for the Detection of Neo-Antigens in X-ray Induced Thymomas of C57BL/6 Mouse

      • A. Artus, B. Guillemain, E. Legrand, R. Mamoun, T. Astier-Gin, J. F. Duplan
      Pages 373-380

    5. Visible Light Induced Killing and Mutation of Acriflavine Sensitized Chinese Hamster Cells

      • Tapan Ganguly, Sukhendu B. Bhattacharjee
      Pages 381-387

    6. Oncogenes Activated in Radiation-Induced Rat Skin Tumors

      • S. J. Garte, M. J. Sawey, F. J. Burns
      Pages 389-397

    7. Mutagenesis in Mammalian Germs Cells by Radiation or Nitrogen Mustard—A Comparative Study

      • Lawrence S. Goldstein
      Pages 399-404

    8. Gene Amplification in Mammalian Cells after Exposure to Ionizing Radiation and UV

      • Christine Lucke-Huhle, Peter Herrlich
      Pages 405-411

    9. Regulation of Gene Expression at the Translational Level in Plant Embryo

      • A. S. N. Reddy, S. Gunnery, A. Datta
      Pages 413-421

  3. Molecular Alterations in DNA

    1. Prooxidant States and Promotion

      • Peter A. Cerutti
      Pages 423-423

    2. Molecular Aspects of DNA Damage and its Modification

      • P. O. ’Neill, E. M. Fielden
      Pages 425-438

    3. 5-Hydroxymethyl Uracil: A Product of Ionizing Radiation and Tritium Transmutation Formed in DNA

      • K. Frenkel, A. Cummings, G. W. Teebor
      Pages 439-445

    4. Characterization of Two CHO Variants in Respect to MNNG-Induced Cell Killing, Mutations, and Repair of Methylated DNA Bases

      • R. Goth-Goldstein, M. Hughes
      Pages 447-451

    5. Investigation of the Sensitivity of Oriented (φX-174 DNA to Ionizing Radiation

      • P. D. McCormack, C. Swenberg
      Pages 453-466

    6. Radiosensitizers and Thymine Base Damage

      • Joyce F. Remsen
      Pages 467-469
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Keywords

About this book

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca­ tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro­ moter. Since breakage of the DNA is one of the principal ways that ion­ izing radiation affects mammalian cells, these new molecular ideas sug­ gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino­ genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

Editors and Affiliations

  • New York University Medical Center, New York, USA

    F. J. Burns, A. C. Upton

  • U.N. Scientific Committee on the Effects of Atomic Radiation, Vienna, Austria

    G. Silini

Bibliographic Information

  • Book Title: Radiation Carcinogenesis and DNA Alterations

  • Editors: F. J. Burns, A. C. Upton, G. Silini

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5269-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4684-5271-6Published: 16 December 2012

  • eBook ISBN: 978-1-4684-5269-3Published: 13 March 2013

  • Edition Number: 1

  • Number of Pages: XI, 618

  • Number of Illustrations: 110 b/w illustrations

  • Topics: Oncology

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