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Radiation Carcinogenesis and DNA Alterations

  • F. J. Burns
  • A. C. Upton
  • G. Silini

Part of the NATO ASI Series book series (NSSA, volume 124)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Carcinogenesis in Humans and Animals

  3. Transformation in Vitro

  4. Ultraviolet Radiation

  5. DNA Strand Breaks and Chromosome Alterations

  6. Mutations and Gene Expression

    1. K. Brown, M. Quintanilla, M. Ramsden, A. Balmain
      Pages 339-351
    2. A. Artus, B. Guillemain, E. Legrand, R. Mamoun, T. Astier-Gin, J. F. Duplan
      Pages 373-380
    3. S. J. Garte, M. J. Sawey, F. J. Burns
      Pages 389-397
    4. Christine Lucke-Huhle, Peter Herrlich
      Pages 405-411
    5. A. S. N. Reddy, S. Gunnery, A. Datta
      Pages 413-421
  7. Molecular Alterations in DNA

  8. Repair of DNA Alterations

  9. Non-Stochastic and Cell Cycle Effects

  10. Models of Radiation Carcinogenesis

About this book

Introduction

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca­ tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro­ moter. Since breakage of the DNA is one of the principal ways that ion­ izing radiation affects mammalian cells, these new molecular ideas sug­ gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino­ genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

Keywords

DNA cancer carcinogenesis lymphoma molecular biology oncogene tumor

Editors and affiliations

  • F. J. Burns
    • 1
  • A. C. Upton
    • 1
  • G. Silini
    • 2
  1. 1.New York University Medical CenterNew YorkUSA
  2. 2.U.N. Scientific Committee on the Effects of Atomic RadiationViennaAustria

Bibliographic information