Advertisement

Regulation of Hepatic Metabolism

Intra- and Intercellular Compartmentation

  • Ronald G. Thurman
  • Frederick C. Kauffman
  • Kurt Jungermann

Table of contents

  1. Front Matter
    Pages i-xix
  2. Liver Structure

    1. Front Matter
      Pages 1-1
    2. Dieter Sasse
      Pages 3-25
    3. P. G. Withrington, P. D. I. Richardson
      Pages 27-53
  3. Methods

    1. Front Matter
      Pages 55-55
    2. Dieter Sasse
      Pages 57-86
    3. Jeffrey Baron, Jeffrey M. Voigt, Thomas T. Kawabata, Jan A. Redick
      Pages 87-118
    4. Frederick C. Kauffman, Franz M. Matschinsky
      Pages 119-136
    5. Kai O. Lindros, Gunnar Bengtsson, Mikko Salaspuro, Hannu Väänänen
      Pages 137-158
    6. John J. Lemasters, Sungchul Ji, Ronald G. Thurman
      Pages 159-184
    7. Bjørn Quistorff, Britton Chance
      Pages 185-207
  4. Distribution of Metabolic Functions

    1. Front Matter
      Pages 209-209
    2. Kurt Jungermann, Norbert Katz
      Pages 211-235
    3. Norbert Katz
      Pages 237-252
    4. Dieter Häussinger, Wolfgang Gerok
      Pages 253-291
    5. Ronald G. Thurman, Sungchul Ji, John J. Lemasters
      Pages 293-320
    6. Ronald G. Thurman, Frederick C. Kauffman, Jeffrey Baron
      Pages 321-382
    7. A. V. LeBouton
      Pages 383-410
    8. Jorge J. Gumucio, William F. Balistreri, Fred J. Suchy
      Pages 411-441
  5. Induction of Liver Cell Heterogeneity

    1. Front Matter
      Pages 443-443
  6. Speculation and Directions for the Future

    1. Front Matter
      Pages 471-471
    2. Ronald G. Thurman, Frederick C. Kauffman, Kurt Jungermann
      Pages 473-475
  7. Back Matter
    Pages 477-489

About this book

Introduction

The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many con­ stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich mixture of nutrients and other absorbed substances via the portal vein and oxygen-rich blood via the hepatic artery. This functional heterogeneity is accompanied by cellular heterogeneity. The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and structurally heterogeneous. The cells in the oxygen-rich areas of the portal triad appear more dependent on oxidative metabolism, whereas those around the central vein (pericentral, perivenous, or centrolobular areas) are more dependent upon an anaerobic mechanism. Throughout this volume the latter three terms are used synonymously by various authors to indicate the five to eight layers of cells radiating from the central vein. Structural and metabolic heterogeneity of hepatic parenchymal cells has been demonstrated by a variety of approaches, including histochemical, ultra­ structural, and ultramicrobiochemical studies. This microheterogeneity is linked to the physiological functions of the liver and its response to injurious substances.

Keywords

Drogen Hormone Lipoprotein antibody bile bile acid cholestasis enterohepatic circulation glucagon gluconeogenesis glycogen hepatotoxicity lipolysis liver metabolism

Editors and affiliations

  • Ronald G. Thurman
    • 1
  • Frederick C. Kauffman
    • 2
  • Kurt Jungermann
    • 3
  1. 1.Department of PharmacologySchool of Medicine, University of North CarolinaChapel HillUSA
  2. 2.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA
  3. 3.Georg-August UniversitätGöttingenFederal Republic of Germany

Bibliographic information