Methods Used in Adenosine Research

  • David M. Paton

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Synthesis and Measurement of Adenosine and Adenine Nucleotide Analogs

  3. Adenosine Metabolism

    1. Front Matter
      Pages 65-65
    2. J. D. Pearson
      Pages 83-107
    3. Ram P. Agarwal
      Pages 109-125
    4. Peter K. Chiang
      Pages 127-145
    5. Johanna D. Stoeckler, Robert E. Parks Jr.
      Pages 147-162
  4. Adenosine Transport

    1. Front Matter
      Pages 163-163
    2. Alan R. P. Paterson, Eric R. Harley, Carol E. Cass
      Pages 165-180
    3. James D. Young, Simon M. Jarvis
      Pages 181-190
  5. Classification and Identification of Receptors for Adenosine and Adenine Nucleotides

    1. Front Matter
      Pages 191-191
    2. Geoffrey Burnstock, Noel J. Buckley
      Pages 193-212
    3. Jeffrey S. Fedan, G. Kurt Hogaboom, John P. O’Donnell, David P. Westfall
      Pages 279-292
    4. R. A. Olsson, R. D. Thompson, S. Kusachi
      Pages 293-304
  6. Physiological Role of Adenosine

  7. Back Matter
    Pages 381-384

About this book


In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine. Another thirty years were to pass before the possible physiological role of adenosine in coronary vasodilation was studied by Berne and others. Since then, there has been a tremendous increase in research into the actions of adenosine. Workers from many disciplines have employed a wide variety of techniques, since adenosine is a product of and a substrate for a number of metabolic pathways, is transported into cells, and acts at discrete receptor sites to modulate the activity of adenylate cyclase and to produce important actions on many cells and tissues including platelets, adipo­ cytes, heart, blood vessels, and other smooth muscles. International symposia on the actions of adenosine were held in 1978, 1981, and 1982, and the proceedings of these symposia have been published (Baer and Drummond, 1979; Daly et at., 1983; Berne et at., 1983). Since it is not the primary purpose of the present volume to review our current understanding of the nu­ merous actions of adenosine, these volumes should be consulted for such details. Rather, the present volume has been planned to provide both graduate students and investigators in pharmacology and related disciplines with a summary of some of the methods now available for the study of the actions of adenosine and, in particular, to highlight their possible uses and limitations.


adenosine blood blood vessel cardiovascular cardiovascular actions cells heart metabolism muscle pharmacology platelet research smooth muscle tissue

Editors and affiliations

  • David M. Paton
    • 1
  1. 1.University of AucklandAucklandNew Zealand

Bibliographic information