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Platelet Membrane Glycoproteins

  • James N. George
  • Alan T. Nurden
  • David R. Phillips

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Plasma Membrane and Membrane Glycoprotein Structure and Function

  4. Interaction of Platelet Membrane Glycoproteins with the Extracellular Environment

    1. Front Matter
      Pages 143-143
    2. David R. Phillips
      Pages 145-169
    3. Deane F. Mosher, Donna M. Pesciotta, Joseph C. Loftus, Ralph M. Albrecht
      Pages 171-191
    4. Joel S. Bennett
      Pages 193-214
    5. Barry S. Coller
      Pages 215-244
    6. Ralph L. Nachman, Lawrence L. K. Leung, Margaret J. Polley
      Pages 245-257
  5. Interactions of Platelet Membrane Glycoproteins with the Intracellular Cytoskeleton

    1. Front Matter
      Pages 271-271
    2. Isaac Cohen
      Pages 299-323
  6. Platelet Membrane Glycoprotein Immunology and Abnormalities

    1. Front Matter
      Pages 325-325
    2. Sharron L. Pfueller
      Pages 327-355
  7. Conclusion

  8. Back Matter
    Pages 413-419

About this book

Introduction

It was just about ten years ago that platelet membrane glycoproteins were first charac­ terized and their abnormalities in congenital bleeding disorders first recognized. Dur­ ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in­ teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contributed major observations and insights during these past years to review their progress and to assess the state of our present knowledge. We have planned this volume to begin with the biochemistry of platelet membrane glycoproteins themselves and proceed through their involvement in platelet function to the final considerations of the platelet's role in maintaining the integrity of the vascular system. Our aim was an integrated presentation on the blood platelet from the perspective of its highly specialized and reactive cell surface. James N. George Alan T. Nurden David R. Phillips vii Contents I. INTRODUCTION 1. Plasma Membrane Receptors and Platelet Response Ernst F. Wscher 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Platelet Receptor Functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . 2. 1. Receptors Involved in Platelet Adhesion and in Cell-Cell Contact. . . 5 2. 2. Receptors Involved in Platelet Activation. . . . . . . . . . . . . . . . . . . 6 . . . . 3. Conclusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 II.

Keywords

Calcium Lipid Oligosaccharid biochemistry enzyme enzymes metabolism protein proteins receptor synthesis

Editors and affiliations

  • James N. George
    • 1
  • Alan T. Nurden
    • 2
  • David R. Phillips
    • 3
  1. 1.Division of Hematology, Department of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Unité 150 INSERMHôpital LariboisièreParis, Cedex 10France
  3. 3.Gladstone Foundation Laboratories for Cardiovascular Disease, Cardiovascular Research Institute, and Department of PathologyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information