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Receptor-Mediated Targeting of Drugs

  • G. Gregoriadis
  • G. Poste
  • J. Senior
  • A. Trouet

Table of contents

  1. Front Matter
    Pages i-x
  2. Y.-J. Schneider, J. Abarca, E. Aboud-Pirak, R. Baurain, F. Ceulemans, D. Deprez-De Campeneere et al.
    Pages 1-25
  3. Harvey R. Herschman, Daniel Cawley, David L. Simpson
    Pages 27-51
  4. M. M. Ponpipom, R. L. Bugianesi, J. C. Robbins, T. W. Doebber, T. Y. Shen
    Pages 53-71
  5. Sjur Olsnes, Kirsten Sandvig, Anders Sundan, Kristin Eiklid, Alexander Pihl
    Pages 87-104
  6. Richard J. Youle, David M. Neville Jr.
    Pages 139-145
  7. F. K. Jansen, H. E. Blythman, B. Bourrie, D. Carriere, P. Casellas, D. Dussossoy et al.
    Pages 147-178
  8. Ellen S. Vitetta, Jonathan W. Uhr
    Pages 179-186
  9. Joyce Taylor-Papadimitriou, Andrew B. Griffiths
    Pages 201-234
  10. Gregory Gregoriadis, Judith Senior, Barbara Wolff, Christopher Kirby
    Pages 243-266
  11. Gerrit Scherphof, Jan Damen, Jan Dijkstra, Frits Roerdink, Halbe Spanjer
    Pages 267-295
  12. Robert M. Straubinger, Keelung Hong, Daniel S. Friend, Nejat Duzgunes, Demetrios Papahadjopoulos
    Pages 297-315
  13. Carl R. Alving, John S. Weldon, John F. Munnell, William L. Hanson
    Pages 317-331
  14. G. B. Humphrey, L. V. Allen, R. Blackstock, P. C. Comp, L. E. De Bault, C. T. Esmon et al.
    Pages 333-345
  15. Vicente J. Caride
    Pages 347-357
  16. Junzo Sunamoto, Mitsuaki Goto, Takaaki Iida, Kohei Hara, Atsushi Saito, Akimitsu Tomonaga
    Pages 359-371
  17. L. D. Leserman, D. Aragnol, J. Barbet, P. Machy, A. Truneh
    Pages 393-405
  18. Timothy Heath, Keith Bragman, Katherine Matthay, Ninfa G. Lopez, Demetrios Papahadjopoulos
    Pages 407-416
  19. J. B. Lloyd, R. Duncan, J. Kopeček, P. Rejmanová
    Pages 417-425
  20. George Poste
    Pages 427-474
  21. Back Matter
    Pages 475-491

About this book

Introduction

Conventional attempts to control cell behaviour and function are often marred by the toxicity of the drugs used, their premature waste or inactivation or by their inability to interact with or reach target sites efficiently. New trends in pharmacology empha­ size the development of methods for the optimization of drug action, for instance by the delivery of drugs, enzymes, hormones, antigens, genetic material, ets. through carrier systems selectively to re­ levant cellular and subcellular sites. A wide assortment of carriers was discussed in the first NATO Advanced Studies Institute (ASI) "Targeting of Drugs," the proceedings of which were published by Plenum Press in 1982 (eds., G. Gregoriadis, J. Senior and A. Trouet). This book, containing the proceedings of the 2nd NATO ASI "Receptor-Mediated Targeting of Drugs" held again at Cape Sounion, Greece during 20 June-l July 1983, deals with drug delivery through systems possessing ligands which can recognize and interact with receptors on the target's surface. Receptor-recognizing carriers that have recently given promise of realistic expectations in targeting include monoclonal antibodies, certain proteins that home to specific cells in the body and liposomes either as such (when they can trigger specific reactions in the reticuloendothelial system) or in association with targeting macromolecules. Each of these are discussed extensively by leading authorities, in terms of applications in biology and medicine and related methodologies.

Keywords

biology enzymes pharmacology protein proteins receptor

Editors and affiliations

  • G. Gregoriadis
    • 1
  • G. Poste
    • 2
  • J. Senior
    • 1
  • A. Trouet
    • 3
    • 4
  1. 1.Royal Free Hospital School of MedicineLondonEngland
  2. 2.Smith Kline & French LaboratoriesPhiladelphiaUSA
  3. 3.International Institute of Cellular and Molecular PathologyBrusselsBelgium
  4. 4.Université Catholique de LouvainBrusselsBelgium

Bibliographic information