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Myocardial Biology

  • Arnold Schwartz

Table of contents

  1. Front Matter
    Pages i-xii
  2. Larry R. Jones, Henry R. Besch Jr.
    Pages 1-12
  3. Mohammed A. Matlib, William Rouslin, Pal L. Vaghy, Arnold Schwartz
    Pages 25-37
  4. Taitzer Wang, Jun Nakamura, Arnold Schwartz
    Pages 39-47
  5. Steven Robertson, James D. Potter
    Pages 63-75
  6. Allan S. Manalan, Larry R. Jones, Henry R. Besch Jr., August M. Watanabe
    Pages 77-94
  7. J. David Johnson, Denise E. Robinson, Laura A. Wittenauer, Douglas A. Fugman
    Pages 95-110
  8. Alan D. Cardin, George Holdsworth, Richard L. Jackson
    Pages 141-166
  9. Back Matter
    Pages 229-236

About this book

Introduction

It is a pleasure to introduce Volume 5 in the Methods in Pharmacology series. In 1971, Volume 1 of this series was published while I was Head of the Division of Myocardial Biology in the Department of Pharmacology at Baylor College of Medicine in Houston, Texas. I dedicated that first volume to Sir Henry Hallet Dale, who died on July 23, 1968. In the Preface I pointed out that many of the pharmacological advancements that occurred during the last century were direct descendants from the classic paper published in 1910 by Professor Dale and his colleague, Dr. Barger. In this paper, the concept of "specific receptor sites" was introduced by the statement that "the relationship of the recepted mechanism to the base [i. e. , drug base] may well be one of solid solution of adsorption and, therefore, more analogous to that of an enzyme to its substrate . . . . " I also pointed out at that time that the search for drug receptors continues and that fundamental knowledge of the nature of receptors and drug-receptor interaction will eventually lead to a rational approach to drug design. Since 1971, the study of receptors and their interaction with specific chemical substances has continued at an accelerated pace and this is due, in particular, to the introduction of new and exciting methodologies. The death last year of Professor Raymond P. Ahl­ quist, who pioneered the introduction of specific adrenergic receptors, represents the close of yet another era.

Keywords

drug lead pharmacology

Editors and affiliations

  • Arnold Schwartz
    • 1
  1. 1.Department of Pharmacology and Cell BiophysicsUniversity of Cincinnati College of MedicineCincinnatiUSA

Bibliographic information