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Genetic Toxicology

An Agricultural Perspective

  • Raymond A. Fleck
  • Alexander Hollaender

Part of the Basic Life Sciences book series (volume 6)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Charles E. Hess
    Pages 1-2
  3. George R. Hoffmann
    Pages 5-27
  4. William M. Upholt
    Pages 37-44
  5. Nemat O. Borhani
    Pages 57-60
  6. Roger R. Connelly
    Pages 61-92
  7. Mortimer L. Mendelsohn
    Pages 113-116
  8. George Bailey, Matthew Taylor, Daniel Selivonchick, Thomas Eisele, Jerry Hendricks, Joseph Nixon et al.
    Pages 149-165
  9. Lucille S. Hurley, Carl L. Keen, Bo Lönnerdal
    Pages 189-199
  10. Donald G. Crosby
    Pages 201-218
  11. David J. Severn
    Pages 235-242
  12. Takashi Sugimura
    Pages 243-269
  13. Michael D. Waters, Shahbeg S. Sandhu, Vincent F. Simmon, Kristien E. Mortelmans, Ann D. Mitchell, Ted A. Jorgenson et al.
    Pages 275-326
  14. James M. Gentile, Michael J. Plewa
    Pages 327-352
  15. R. Julian Preston
    Pages 379-388
  16. Richard J. Albertini, David L. Sylwester, Bruce D. Dannenberg, Elizabeth F. Allen
    Pages 403-424
  17. Richard H. Reitz, Alan M. Schumann, Philip G. Watanabe, Perry J. Gehring
    Pages 425-438
  18. Burke K. Zimmerman
    Pages 439-460
  19. D. Krewski, D. Clayson, B. Collins, I. C. Munro
    Pages 461-497
  20. Bruce N. Ames
    Pages 499-508
  21. Back Matter
    Pages 533-550

About this book

Introduction

To meet the needs of an ever-growing world population for food and fiber, agriculture uses an arsenal of chemicals to control insects, weeds and other pests that compete with man in the agricultural arena. In addition to their intended effect, many of these biologically active materials affect non-target organisms including man himself. There is concern about the resulting occupational exposure of those who work in agriculture and the environmental health of those who live in rural areas. Unintended side effects from the use of agricultural chemicals are further complicated by the dispersal of these substances well beyond the area of immediate use, through food chains, atmospheric transport, irrigation runoff, percolation to and diffusion through ground­ water, sometimes giving rise to public health and environmental problems at a distance from the place of application. In addition to toxic substances introduced into the agro­ ecosystem by man, one must be concerned about naturally occurring agents including mfcotoxins, plant poisons, infective biological agents and the levels of certain heavy metals. The formation of toxic substances, many of them mutagenic, during cooking and other processing of food is a related problem. While acute effects are more immediate and somewhat readily discerned, chronic and genetic effects tend to be more obscure and sometimes surface in a crisis situation long after substantial damage has been sustained. Genotoxicity assays and epidemiological studies play increasing roles in predicting and evaluating long­ term effects of low-level exposure to toxic materials.

Keywords

ecosystem environment heavy metal toxicity toxicology

Editors and affiliations

  • Raymond A. Fleck
    • 1
  • Alexander Hollaender
    • 2
  1. 1.University of California, DavisDavisUSA
  2. 2.Associated Universities, Inc.USA

Bibliographic information