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Nephrotoxic Mechanisms of Drugs and Environmental Toxins

  • George A. Porter

Table of contents

  1. Front Matter
    Pages i-xix
  2. Pathophysiology of Acute Renal Failure

    1. Front Matter
      Pages 1-1
    2. Jeffrey I. Kreisberg, Erve G. J. Matthys, Manjeri A. Venkatachalam
      Pages 11-23
    3. N. Lameire, R. Vanholder, L. Vakaet, P. Pattyn, S. Ringoir, J. Quatacker
      Pages 37-56
    4. Roland C. Blantz
      Pages 57-64
    5. Walter Flamenbaum, James Kaufman, Shreekant Chopra, Marc Gehr, Robert Hamburger
      Pages 65-76
    6. Philip R. Steinmetz, Russell F. Husted
      Pages 95-98
  3. Renal Failure Due to Antimicrobial Agents

    1. Front Matter
      Pages 99-99
    2. George A. Porter
      Pages 101-105
    3. William M. Bennett, Donald C. Houghton, W. Clayton Elliott
      Pages 107-116
    4. J. P. Morin, G. Viotte, J. P. Bendirdjian, B. Olier, J. P. Fillastre, M. Godin
      Pages 117-134
    5. Friedrich C. Luft
      Pages 135-150
    6. Bruce M. Tune
      Pages 151-164
    7. Malcolm Cox
      Pages 165-177
  4. Tubulointerstitial Nephropathy Due to Drugs and Environmental Toxicants

    1. Front Matter
      Pages 179-179
    2. George A. Porter
      Pages 181-187
    3. Ramzi S. Cotran
      Pages 189-195
    4. Thomas G. Murray
      Pages 197-208
    5. Gilbert H. Mudge
      Pages 209-225
    6. Philip W. Hall III
      Pages 227-240
    7. William O. Berndt
      Pages 241-254
    8. Richard P. Wedeen
      Pages 255-265
    9. P. B. Hammond, C. D. Hong, E. J. O‘Flaherty, S. I. Lerner, I. B. Hanenson
      Pages 267-277
  5. Pathophysiologic Mechanisms of Toxicity Induced by Environmental Toxicants

    1. Front Matter
      Pages 279-279
    2. Jerry B. Hook
      Pages 281-283
    3. Gunnar F. Nordberg
      Pages 285-303
    4. Robert A. Goyer
      Pages 305-313
    5. William M. Kluwe
      Pages 331-344
    6. William R. Hewitt, Esther M. Brown, Michel G. Côté, Gabriel L. Plaa, Hiroakil Miyajima
      Pages 357-365
  6. Immunologic Mechanisms and Toxic Nephropathies

    1. Front Matter
      Pages 367-367
    2. Giuseppe A. Andres
      Pages 369-371
    3. Joseph P. Portanova, Robert L. Rubin, Eng M. Tan
      Pages 373-381
    4. Curtis B. Wilson
      Pages 383-392
    5. Robert T. McCluskey, Atul K. Bhan
      Pages 393-402
    6. Wayne A. Border
      Pages 403-408
    7. Timo Palosuo, Felix Milgrom
      Pages 409-412
    8. B. Albini, I. Glurich, Giuseppe A. Andres
      Pages 413-423
    9. Philippe Druet, Catherine Sapin, Elvira Druet, François Hirsch
      Pages 425-435
  7. Back Matter
    Pages 451-466

About this book

Introduction

The majority of the offending toxicants to be reviewed in this volume were devel­ oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip­ tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem.

Keywords

Ketone Pet dialysis environment etiology iron natural product toxicity

Editors and affiliations

  • George A. Porter
    • 1
  1. 1.University of Oregon Health Science CenterPortlandUSA

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