Melanoma Antigens and Antibodies

1. Front Matter

   Pages i-xvii

   PDF

2. Immunogenetics of Melanoma

   • Ronald T. Acton, Charles M. Balch, Bruce Budowle, Rodney C. P. Go, Jeffrey M. Roseman, Seng-Jaw Soong et al.

   Pages 1-21

3. Indomethacin, Prostaglandin, and Immune Regulation in Melanoma

   • Charles M. Balch, Arabella B. Tilden

   Pages 23-35

4. Shedding and Degradation of Cell-Surface Macromolecules and Melanoma-Associated Antigens by Human Melanoma

   • Jean-Claude Bystryn

   Pages 37-52

5. Monoclonal Antibodies as a Tool to Detect Melanoma-Associated Antigens

   • Stefan Carrel, Roberto S. Accolla, Jean-Pierre Mach, Nicole Gross

   Pages 53-73

6. Tumor-Directed Cellular Immunity in Malignant Melanoma and the Antigens That Evoke It

   • Alistair J. Cochran

   Pages 75-99

7. Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera

   • Peter B. Dent, Shuen-Kuei Liao

   Pages 101-122

8. Protein Antigens of Mouse Melanomas

   • Douglas M. Gersten, John J. Marchalonis

   Pages 123-138

9. Clinical Significance of Tumor-Associated Antigens and Antitumor Antibodies in Human Malignant Melanoma

   • Rishab K. Gupta, Donald L. Morton

   Pages 139-172

10. Specificity of Cell-Mediated Immunoreactivity in Melanoma and Comments on the Nature of Serum Blocking Factors

    • W. J. Halliday

    Pages 173-186

11. Antigens in Human Melanomas Detected by Using Monoclonal Antibodies as Probes

    • Karl Erik Hellström, Ingegerd Hellström

    Pages 187-209

12. The Nature and Significance of Melanoma Antigens Recognized by Human Subjects

    • Peter Hersey, William H. McCarthy

    Pages 211-233

13. Cellular and Humoral Studies of Malignant Melanoma

    • Ariel Hollinshead, Keith Tanner, W. Daniel Kundin

    Pages 235-250

14. Immunodiagnosis of Human Melanoma: Detection of Circulating Melanoma-Associated Antigens by Radioimmunoassay

    • Yoshifumi Ishii, Giora M. Mavligit

    Pages 251-262

15. The Association between Antigens of Human Malignant-Melanoma Cells and Mycobacterium bovis (BCG)

    • Percy Minden, Peter J. Kelleher, Linda K. Woods

    Pages 263-277

16. Monoclonal Antibodies to Human Melanoma-Associated Antigens: Elicitation and Evaluation with Immunochemically Defined Antigen Preparations

    • Alton C. Morgan Jr.

    Pages 279-288

17. The Significance of Circulating Immune Complexes in Patients with Malignant Melanoma

    • T. M. Phillips, W. D. Queen, M. G. Lewis

    Pages 289-316

18. Molecular and Immunological Characterization of Human Melanoma-Associated Antigens

    • R. A. Reisfeld, D. R. Galloway, R. P. McCabe, Alton C. Morgan Jr.

    Pages 317-337

19. Cell-Surface Structure and State of Malignancy in Human Malignant Melanoma

    • Clemens Sorg, Josef Brüggen, Dorothea Terbrack, Fereydoun Vakilzadeh, Ludwig Suter, Egon Macher

    Pages 339-354

20. Immunotherapy of Melanoma

    • Lynn E. Spitler, Charles Scott

    Pages 355-363

The ever-expanding research on human cancer has resulted in numerous technical and conceptual advances during the last few years. Serological, structural, and biological char­ acterization of human melanoma constitutes one area of research that has received consid­ erable attention from researchers and clinicians and has generated new and exciting infor­ mation. In this volume, we have attempted to assemble work on topics that produced some of the most recent advances. We asked each author to describe and interpret his most cur­ rent research and, whenever possible, to compare and contrast it with work of other inves­ tigators in the field. We have been careful not to impose our viewpoints except in contri­ butions from our own laboratories, since we want to provide the reader with as many divergent and sometimes opposing viewpoints as feasible. Therefore, we have not been overly concerned with overlaps in some individual topics. We hope that this volume will provide the reader with a well-balanced overview of current problems and ideas in a par­ ticular area of cancer research. We wish to express our thanks to all contributors for their timely and very interesting manuscripts, and we sincerely hope that the reader will enjoy this volume and benefit as much from it as we did. R. A. Reisfeld S. Ferrone La Jolla ix Contents CHAPTER 1 Immunogenetics of Melanoma RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. Go, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

• antibody
• antigen
• cancer
• cancer research
• genetics
• melanoma
• antibodies

• Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

  Ralph A. Reisfeld

• Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, USA

  Soldano Ferrone

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