Brain Chemistry and Mental Disease

Proceedings of a Symposium on Brain Chemistry and Mental Disease held at the Texas Research Institute, Houston, Texas, November 18–20, 1970

  • Beng T. Ho
  • William M. McIsaac

Part of the Advances in Behavioral Biology book series (ABBI, volume 1)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Enzymes: Implications in Mental Disease

  3. Psychoactive Agents: Biological Actions

  4. Biological Aspects of Affective Disorders

    1. Alec Coppen
      Pages 123-133
    2. Elliot S. Gershon, William E. Bunney Jr., Frederick K. Goodwin, Dennis L. Murphy, David L. Dunner, George M. Henry
      Pages 135-161
    3. Arthur J. Prange Jr., Ian C. Wilson, Angelina E. Knox, Thomas K. McClane, George R. Breese, Billy R. Martin et al.
      Pages 197-213
    4. Joseph J. Schildkraut, Paul R. Draskoczy, Elliot S. Gershon, Peter Reich, Edwin L. Grab
      Pages 215-236
  5. Brain Amines and Affective Disorders

    1. Seymour Kety
      Pages 237-244
    2. Beng T. Ho, William M. McIsaac
      Pages 245-263
  6. Genetic and Metabolic Factors in Mental Disorders

  7. Modern Concepts of Chemotherapy

    1. Leo E. Hollister
      Pages 303-317
    2. Baron Shopsin, Samuel Gershon
      Pages 319-377
    3. Gerald L. Klerman
      Pages 379-402
  8. Back Matter
    Pages 403-411

About this book


This volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases. Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. Studies concerning the proposed catecholamine and indolealkylamine hypotheses for affective disorders and the possible formation of endogenous. toxins in schizophrenia have stimulated significant new research. This book presents new studies of schizophrenia and the affective disorders in one volume. It is our hope that it represents an effective integration of basic biochemical and pharmacological research with current clinical findings and that it will increase understanding of the etiology of mental disease and provide an impetus for the development of more effective therapeutic agents. We thank Drs. Gordon Farrell, Samuel Gershon, A. Horita, Irwin Kopin, and Joseph Schildkraut for their help with the organization of the meeting and for chairing the corresponding sessions.


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Editors and affiliations

  • Beng T. Ho
    • 1
  • William M. McIsaac
    • 1
  1. 1.Texas Research Institute of Mental SciencesTexas Medical CenterHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1971
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3059-2
  • Online ISBN 978-1-4684-3057-8
  • Series Print ISSN 0099-6246
  • Buy this book on publisher's site