Biological Amplification Systems in Immunology

  • Noorbibi K. Day
  • Robert A. Good

Part of the Comprehensive Immunology book series (COMIMUN, volume 2)

Table of contents

  1. Front Matter
    Pages i-xv
  2. W. Opferkuch, M. Segerling
    Pages 1-16
  3. Henry Gewurz, Thomas F. Lint
    Pages 17-45
  4. Harvey R. Colten
    Pages 47-67
  5. Celso Bianco
    Pages 69-84
  6. Frank M. Griffin Jr.
    Pages 85-113
  7. Sarkis H. Ohanian, Tibor Borsos
    Pages 115-135
  8. Louis H. Muschel, Jack S. C. Fong
    Pages 137-158
  9. Ralph Snyderman, Marilyn Pike
    Pages 159-181
  10. Richard J. Ulevitch, Charles G. Cochrane
    Pages 205-217
  11. Hartmut Geiger, Noorbibi K. Day
    Pages 219-228
  12. Noorbibi K. Day, B. Moncada, Robert A. Good
    Pages 229-245
  13. Casper Jersild, Pablo Rubinstein, Noorbibi K. Day
    Pages 247-275
  14. Robert L. Kassel, William D. Hardy Jr., Noorbibi K. Day
    Pages 277-294
  15. Irma Gigli
    Pages 295-313
  16. Back Matter
    Pages 315-325

About this book


Interest in complement developed at the end of the nineteenth century from observations on cellular and humoral defense mechanisms against bacteria. It was recognized at that time that there were factors in body fluids of animals and man that were capable of killing and lysing bacteria in the absence of cellular factors. Due to the efforts of two of the founders of immunology, Bordet and Ehrlich, and their colleagues, by 1912 the multicomponent nature of complement action was well recognized, the sequence of reaction of the components in the lysis of erythrocytes was defined, complement fixation as a major tool for studying antibody-antigen interaction was well established, and studies on the physicochemical properties of the components had been started. Yet, with a few notable exceptions, research on complement was largely abandoned by most "mainstream" immunologists for the following two or three decades. When one looks at the contents of the present volume, it is hard to imagine that as recently as 20 years ago, there were probably fewer than ten major laboratories where complement research was the primary theme. The contents attest to the fact that there are today dozens of laboratories on three continents where research on complement is pursued in depth. It is not easy to point to all the advances that have occurred in complement research during the past few years.


antibody antigen bacteria immunology

Editors and affiliations

  • Noorbibi K. Day
    • 1
  • Robert A. Good
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

Bibliographic information