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Preimplantation Genetics

  • Yury Verlinsky
  • Anver Kuliev

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

    1. Robert G. Edwards
      Pages 1-7
  3. Embryological Aspects of Preimplantation Genetics

    1. Front Matter
      Pages 9-9
    2. Joseph Schulman
      Pages 11-14
  4. Micromanipulation and Biopsy of Gametes and Preembryos

    1. Front Matter
      Pages 37-37
    2. Yury Verlinsky
      Pages 39-47
    3. Jacques Cohen, Mina Alikani, Henry Malter, Beth Talansky, Michael Tucker, Sharon Wiker et al.
      Pages 63-74
    4. Sandra Carson
      Pages 85-88
  5. Genetic Analysis of Gametes and Preembryos

    1. Front Matter
      Pages 89-89
    2. Renee Martin
      Pages 91-102
    3. Michelle Plachot
      Pages 103-112
    4. Norman Arnheim, Honghua Li, Xiangfeng Cui, William Navidi
      Pages 121-130
    5. Charles M. Strom, Gloria Enriquez, Svetlana Rechitsky
      Pages 131-138
    6. Eleni H. Kontogianni, Kate Hardy, Alan H. Handyside
      Pages 139-145
    7. Jamie A. Grifo, David C. Ward, Ann Boyle
      Pages 147-152
  6. Clinical Aspects of Preimplantation Genetics

    1. Front Matter
      Pages 153-153
    2. Andre Van Steirteghem, Jiaen Liu, Etienne Van den Abbeel, Inge Liebaers, Paul Devroey
      Pages 155-164
    3. Bruno Brambati, Leonardo Formigli
      Pages 165-174
  7. Gene Expression in Preimplantation Development and Gene Therapy

    1. Front Matter
      Pages 187-187
    2. Claudia Kappen, Frank H. Ruddle
      Pages 189-201
    3. Robert P. Erickson
      Pages 203-211
    4. Arthur Bank
      Pages 213-219
  8. Ethical and Legal Aspects of Preimplantation Genetics

    1. Front Matter
      Pages 231-231
    2. Anver Kuliev, Bernadette Modell
      Pages 233-244
  9. Technical Aspects of Preimplantation Genetics

    1. Front Matter
      Pages 271-271
    2. Yury Verlinsky, Jeanine Cieslak, Sergei Evsikov
      Pages 273-278
    3. Henry E. Malter, Beth E. Talansky, Jacques Cohen
      Pages 279-284
    4. Renee Martin, Evelyn Ko, Leona Barclay
      Pages 285-292
    5. Svetlana Rechitsky, Gloria Enriquez, Charles M. Strom
      Pages 305-312
    6. Joe Leigh Simpson
      Pages 313-317
  10. Back Matter
    Pages 319-325

About this book

Introduction

Yury Verlinskyand Anver Kuliev Reproductive Genetics Institute, Illinois Masonic Medical Center, 836 W. Wellington chicago, IL 60657 Although introduction of a first trimester prenatal diagnosis by chorionic viIIus sampling (CVS) has considerably improved the possibility for prevention of genetic diseases, it requires a selective abortion in case of an affected fetus. Following the direction of an earlier prenatal diagnosis and to avoid the need for abortion, preimplantation genetic diagnosis has been initiated based on polar body removal and pre-embryo biopsy. The First International symposium on Preimplantation Genetics, Chicago, September 17-19, 1990, was organized to explore these important developments, to review the state of knowledge in the field, and to address existing problems to be solved for developing and improving current approaches for preimplantation diagnosis of genetic disorders. A growing interest in the subject was obvious from the wide attendance of the meeting: over 250 scientists from 19 countries participated. This was the first attempt to put together the advances in different areas of basic and applied research relevant to Preimplantation Genetic Diagnosis, with the multidisciplinary scientific program including the sessions on embryology, micromanipulation and biopsy, genetic analysis of gametes and pre-embryos, IVF, gene expression and gene therapy, and ethical and legal issues. The deliberations of the Symposium presented in the above mentioned sessions, which comprise the contents of correspond­ ing sections of the Proceedings, open a newarea in medical research based on the interaction of IVF and New Genetics.

Keywords

Chromosom DNA Embryo Evolution PCR enzymes gene expression gene therapy genes genetics hybridization mammalian oocytes

Editors and affiliations

  • Yury Verlinsky
    • 1
  • Anver Kuliev
    • 1
  1. 1.Reproductive Genetics InstituteChicagoUSA

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