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Primary Photo-Processes in Biology and Medicine

  • R. V. Bensasson
  • G. Jori
  • E. J. Land
  • T. G. Truscott

Table of contents

  1. Front Matter
    Pages i-xiv
  2. T. G. Truscott
    Pages 25-34
  3. E. J. Land, C. J. Willsher, A. Garner, G. Scholes, Ian Wilson, Kathryn R. Bretscher et al.
    Pages 35-64
  4. J. W. Petrich, M. C. Chang, G. R. Fleming, Albert J. Cross, Mary C. Chang, Graham R. Fleming et al.
    Pages 77-91
  5. Robert Wilbrandt, Niels-Henrik Jensen, C. Houée-Levin, R. V. Bensasson
    Pages 93-109
  6. P. J. Hore, J. Marko, G. Vermeersch, N. Febvay-Garot, A. Lablache-Combier, J. Kemmink et al.
    Pages 111-130
  7. P. J. Hore
    Pages 131-145
  8. Silvia E. Braslavsky, K. Heihoff, N. A. Garcia, G. Rossbroich, H. Dürr, Patrick Poulet et al.
    Pages 147-170
  9. Michael A. J. Rodgers, G. Rossbroich, N. A. Garcia, S. E. Braslavsky, A. A. Gorman, I. Hamblett et al.
    Pages 181-207
  10. Jacques Piette
    Pages 229-240
  11. R. V. Bensasson, A. Andreoni, R. Cubeddu, F. Dall’Acqua, C. N. Knox, T. G. Truscott
    Pages 241-258
  12. Francesco Dall’Acqua, Sergio Caffieri, Giovanni Rodighiero, F. Gaboriau, P. Vigny, J. Cadet et al.
    Pages 259-276
  13. Francesco Dall’Acqua, Giovanni Rodighiero, Dietrich Averbeck, Simone Averbeck, Neil K. Gibbs, Antony R. Young et al.
    Pages 277-307
  14. T. G. Truscott, Antony F. McDonagh, David A. Lightner, C. Lambert, M. A. J. Rodgers, G. Jori et al.
    Pages 309-347
  15. Giulio Jori, Elena Reddi, R. C. Straight, J. D. Spikes, T. Sicuro, P. Carlini et al.
    Pages 349-369
  16. Giulio Jori, Ivo Cozzani, Maria F. Vigna, Antonio Tau, T. M. A. R. Dubbelman, J. P. J. Boegheim et al.
    Pages 381-424
  17. L. Dubertret, Silvia Schauder, G. M. J. Beijersbergen van Henegouwen, P. J. G. Cornelissen, A. Bakri, H. de Vries et al.
    Pages 425-445
  18. J. A. Parrish, C. R. Shea
    Pages 447-452
  19. Back Matter
    Pages 463-478

About this book

Introduction

Recently there have been major developments in the experimental techniques available for the study of the primary events following the absorption of ultra-violet and visible radiation by biological systems. These techniques, which include absorption, emission, resonance Raman, electron spin resonance, nuclear magnetic resonance and photoacoustic spectroscopies, can be used to study the fate of transient species with lifetimes ranging from seconds to nanoseconds and extending in some cases, such as laser flash photolysis, to pico 12 15 (10- S)- and even femtoseconds (10- s). In parallel with these developments there has been a dramatic increase in the use of light in medicine via the direct photochemical alteration of endogenous molecules (phototherapy) or via the photoactivation of drugs in the skin or other tissue (photochemotherapy). Thus neonatal hyperbili­ rubinaemia can be routinely treated by phototherapy and psoriasis is frequently treated by PUVA photochemotherapy. A promising new photo­ chemotherapy used the phototoxicity of porphyrin drugs activated by red light to destroy solid malignant tumors. While some of the overall qualitative effects of such treatments are known, only recently have we begun to understand the associated molecular mechanisms. The primary molecular processes involve short-lived species. The pur­ pose of this Advanced Study Institute was to review some newer experi­ mental techniques for the study of such species, the application of these techniques to biological and medical systems and to examine the value of such information in phototherapeutic situations.

Keywords

biology experiment information medicine

Editors and affiliations

  • R. V. Bensasson
    • 1
  • G. Jori
    • 2
  • E. J. Land
    • 3
  • T. G. Truscott
    • 4
  1. 1.Muséum National d’Histoire NaturelleParisFrance
  2. 2.University of PaduaPaduaItaly
  3. 3.Christie Hospital and Holt Radium InstituteManchesterEngland
  4. 4.Paisley College of TechnologyPaisleyScotland

Bibliographic information