Endorphins and Opiate Antagonists in Psychiatric Research

Clinical Implications

  • Nandkumar S. Shah
  • Alexander G. Donald

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Richard D. Olson, Abba J. Kastin, Gayle A. Olson, David H. Coy
    Pages 61-73
  3. Alexander Jakubovic
    Pages 89-97
  4. A. Dupont, Y. Mérand, D. Rouleau, L. Cusan, A. Lemay, H. Vaudry et al.
    Pages 99-126
  5. Viktor Havlicek, Michael West, Nobumasa Kato, Henry G. Friesen
    Pages 127-159
  6. Jambur Ananth, Vasvan Nair, Ram Rastogi
    Pages 179-212
  7. W. M. A. Verhoeven, H. M. van Praag
    Pages 213-229
  8. V. Höllt, H. M. Emrich, M. Bergmann, N. Nedopil, D. Dieterle, H. J. Gurland et al.
    Pages 231-243
  9. L. H. Lindström, G. Besev, L-M. Gunne, R. Sjöström, L. Terenius, A. Wahlstrom et al.
    Pages 245-256
  10. Robert H. Gerner, David A. Gorelick, Don H. Catlin, Cho Hao Li
    Pages 257-270
  11. Roberta M. Palmour, Frank R. Ervin
    Pages 311-331
  12. J. Robert Cade, Herbert Wagemaker, Alexander M. C. Macgregor
    Pages 333-345

About this book


The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha­ nisms mediating the synaptic action, and to the appraisal of the involve­ ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.


communication evaluation regulation research value-at-risk

Editors and affiliations

  • Nandkumar S. Shah
    • 1
  • Alexander G. Donald
    • 2
  1. 1.William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of PharmacologyUniversity of South Carolina School of MedicineColumbiaUSA
  2. 2.William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral SciencesUniversity of South Carolina School of MedicineColumbiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-1119-5
  • Copyright Information Springer-Verlag US 1982
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-1121-8
  • Online ISBN 978-1-4684-1119-5
  • About this book