Heparin

Structure, Function, and Clinical Implications

  • Ralph A. Bradshaw
  • Stanford Wessler

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 52)

Table of contents

  1. Front Matter
    Pages i-x
  2. Structural Aspects

    1. Front Matter
      Pages 1-1
    2. Molecular Properties

      1. Roger W. Jeanloz
        Pages 3-17
      2. Edward D. T. Atkins, Ian A. Nieduszynski
        Pages 19-37
      3. Leon Yuan, Salvatore S. Stivala
        Pages 39-49
    3. Biosynthesis

      1. Jeremiah E. Silbert, Hynda K. Kleinman, Cynthia K. Silbert
        Pages 51-60
      2. Gudrun Bäckström, Anund Hallen, Magnus Höök, Leif Jansson, Ulf Lindahl
        Pages 61-77
    4. Biological Properties

    5. Analytical and Pharmacological Considerations

  3. Functional Aspects

    1. Front Matter
      Pages 193-193
    2. Effect on Blood Coagulation: Interaction with Antithrombin III

About this book

Introduction

The International Symposium on Heparin, held May 13-15, 1974, in St. Louis, Missouri, as a part of the dedication of the Shoenberg Pavilion of the Jewish Hospital of St. Louis, was conceived as a forum to bring together physicians and scientists with a basic in­ terest in the structure, function and clinical usefulness of heparin. Few naturally occurring substances have commanded the breadth of interest among members of the biomedical research community as this compound has. Aspects of its covalent and three-dimensional struc­ ture, its biosynthesis, its interaction with and effect on physio­ logically important moieties and its use as a therapeutic agent in a variety of disease states have been actively studied for the past several decades. Thus, the present state of these studies seemed to be a timely subject for discussion, not only to gather together in one place representative samples of the myriad of data on heparin but also to underscore the ever increasing necessity for communica­ tion between basic research and clinical practice.

Keywords

Lipoprotein artery biomedical research biosynthesis blood embolism hospital metabolism myocardial infarction plasma platelet research thrombosis

Editors and affiliations

  • Ralph A. Bradshaw
    • 1
  • Stanford Wessler
    • 2
    • 3
  1. 1.Department of Biological ChemistryWashington University School of MedicineSt. LouisUSA
  2. 2.Department of MedicineThe Jewish HospitalSt. LouisUSA
  3. 3.Washington University School of MedicineSt. LouisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-0946-8
  • Copyright Information Plenum Press, New York 1975
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-0948-2
  • Online ISBN 978-1-4684-0946-8
  • Series Print ISSN 0065-2598
  • About this book