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Mechanisms of DNA Damage and Repair

Implications for Carcinogenesis and Risk Assessment

  • Book
  • © 1986

Overview

Editors:
  1. Michael G. Simic

    1. National Bureau of Standards, Gaithersburg, USA
      Chemistry Department, American University, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Lawrence Grossman

    1. Johns Hopkins University, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Arthur C. Upton

    1. New York University Medical Center, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  4. David S. Bergtold
    View editor publications

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Part of the book series: Basic Life Sciences (BLSC, volume 38)

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Table of contents (60 chapters)

  1. DNA Damage

    2. DNA Binding Drugs

      1. Sequence Specificity and Biological Consequences of Drugs that Bind Covalently in the Minor Groove of DNA
        • Laurence H. Hurley, Donald R. Needham-VanDevanter
        Pages 203-210
      2. Molecular Recognition of DNA Binding Agents: High-Field 1H and 3 1P One- and Two-Dimensional NMR Studies on the 1:1 Intercalation Complexes of Mitoxantrone with Selected Oligodeoxyribonucleotides
        • Albin Otter, Christopher C. Hanstock, George Kotovych, Bernard Rayner, Jacques J. Vasseur, Jean-Louis Imbach et al.
        Pages 211-218
      3. DNA Binding and Biological Properties of Bis and Tris Interacting Molecules
        • Jean-Bernard Le Pecq, Bernard P. Roques
        Pages 219-230
      4. Novel Types of DNA-Sugar Damage in Neocarzinostatin Cytotoxicity and Mutagenesis
        • Irving H. Goldberg
        Pages 231-244
      5. DNA-Drug Binding and Control of Genetic Information
        • Richard E. Dickerson
        Pages 245-255
      6. Computer-Aided Design of New DNA Intercalators
        • Stephen Neidle
        Pages 257-264

  2. DNA Repair and Consequences

    1. Differential Expression of SOS Genes in an E. Coli Mutant Producing Unstable LexA Protein Enhances Excision Repair But Inhibits Mutagenesis

      • Kenneth R. Peterson, Ann K. Ganesan, David W. Mount
      Pages 265-271

    2. Mutagenic DNA Repair in Bacteria: The Role of UmuDC and MucAB

      • Lorraine Marsh, Graham C. Walker
      Pages 273-280

    3. The Repair of Pyrimidine Dimers Via a DNA-Glycosylase Mechanism

      • Robert H. Grafstrom
      Pages 281-286

    4. The Involvement of an E. Coli Multiprotein Complex in the Complete Repair of UV-Damaged DNA

      • Lawrence Grossman, Paul R. Caron, Euk Y. Oh
      Pages 287-294

    5. Pyrimidine Dimers Induced Alteration of DNA Tertiary Structure Evidence for Unwinding and Shortening

      • Antonia M. Pedrini, Silvia Tornaletti, Paola Menichini, Angelo Abbondandolo
      Pages 295-301

    6. Mismatch Correction

      • Paul Modrich
      Pages 303-310

    7. Molecular Approaches to the Study of Nucleotide Excision Repair in Eukaryotes

      • E. C. Friedberg, D. P. Barbis, J. M. Chenevert, R. Fleer, D. Kalainov, L. Naumovski et al.
      Pages 311-318

    8. Restoration of DNA Repair in UV-Sensitive Chinese Hamster Ovary Cell by the denV Gene from Bacteriophage T4

      • Kristoffer Valerie, Jon K. de Riel, Earl E. Henderson
      Pages 319-326

    9. The Adaptive Response of Mammalian Cells to Alkylating Agents

      • Leona Samson
      Pages 327-334

    10. DNA Glycosylases in DNA Repair

      • Tomas Lindahl
      Pages 335-340

    11. Apurinic Sites as Common Intermediates in Mutagenesis

      • Lawrence A. Loeb, Bradley D. Preston, Elizabeth T. Snow, Roeland M. Schaaper
      Pages 341-347

    12. The Repair of Uracil-Containing DNA

      • Bernard Weiss, Hiyam H. El-Hajj
      Pages 349-356

    13. Metabolic Consequences of DNA Damage: The Role of Poly (ADP-Ribose) Polymerase as Mediator of the Suicide Response

      • Nathan A. Berger, Sosamma J. Berger
      Pages 357-363
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Keywords

About this book

This book is based on the papers presented at the conference on "Mecha­ nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Editors and Affiliations

  • National Bureau of Standards, Gaithersburg, USA

    Michael G. Simic

  • Chemistry Department, American University, USA

    Michael G. Simic

  • Johns Hopkins University, Baltimore, USA

    Lawrence Grossman

  • New York University Medical Center, New York, USA

    Arthur C. Upton

Bibliographic Information

  • Book Title: Mechanisms of DNA Damage and Repair

  • Book Subtitle: Implications for Carcinogenesis and Risk Assessment

  • Editors: Michael G. Simic, Lawrence Grossman, Arthur C. Upton, David S. Bergtold

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4615-9462-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4615-9464-2Published: 22 December 2012

  • eBook ISBN: 978-1-4615-9462-8Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: XV, 578

  • Topics: Organic Chemistry

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