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Immunobiology of Proteins and Peptides · I

  • M. Z. Atassi
  • A. B. Stavitsky

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 98)

Table of contents

  1. Front Matter
    Pages i-x
  2. Antigenic Structure of Proteins

  3. Immunobiology of Proteins and Peptides

    1. Front Matter
      Pages 141-141
    2. Joel W. Goodman, Sherman Fong, George K. Lewis, Roberta Kamin, Danute E. Nitecki, Georges Der Balian
      Pages 143-164
    3. Eli Benjamini, Cherry Y. Leung, Donna M. Rennick
      Pages 165-179
    4. A. B. Stavitsky, M. Z. Atassi, G. T. Gooch, G. L. Manderino, W. W. Harold, R. P. Pelley et al.
      Pages 199-223
    5. Jay A. Berzofsky, David S. Pisetsky, Ronald H. Schwartz, Alan N. Schechter, David H. Sachs
      Pages 241-257
    6. E. H. Eylar
      Pages 259-281
    7. Robert J. Scibienski, Vicki Klingmann, Cherry Leung, Karen Thompson, Eli Benjamini, Marc Feldmann
      Pages 305-321
  4. Immunobiology of Protein Conjugates

    1. Front Matter
      Pages 323-323
    2. M. Baltz, P. Erb, M. Feldmann, S. Howie, S. Kontiainen, A. Torano
      Pages 325-338
    3. George K. Lewis, Joel W. Goodman, Raymond Ranken
      Pages 339-356
    4. R. W. Warren, R. C. Griffith, J. M. Davie
      Pages 357-369
    5. Ronald H. Schwartz, Alan M. Solinger, Michiel Ultee, Emanuel Margoliash
      Pages 371-386
  5. Immune Responses to Synthetic Polymers and to Proteins

    1. Front Matter
      Pages 399-399
    2. David H. Katz
      Pages 401-402
    3. A. Campos-Neto, H. Levine, S. F. Schlossman
      Pages 403-417
    4. Alan S. Rosenthal, Lanny J. Rosenwasser, Bonita L. Baskin, Joyce Schroer, James W. Thomas, J. Thomas Blake
      Pages 447-458
    5. Paul H. Maurer, Allen R. Zeiger, Carmen F. Merryman, Chang-Hai Lai
      Pages 459-474
  6. Lymphocyte Membrane Structure

    1. Front Matter
      Pages 475-475
    2. Leon Wofsy
      Pages 477-482
    3. Noel L. Warner, Alan W. Harris, I. F. C. McKenzie, D. De Luca, G. Gutman
      Pages 483-495
  7. Back Matter
    Pages 497-513

About this book

Introduction

One of the central questions in immunology is the understanding in molecular terms of antigen-antibody interactions and of the cellu­ lar recognition of antigens. It is hoped that this understanding will extend eventually to the immunobiological basis of host defense to infectious agents and of tissue damage or deranged cell functions which stem from these reactions. A variety of natural and artificial substances have been used as models for these studies. Emphasis was placed upon substances of known and relatively uncomplicated chemical structures. These included polysaccharides, amino acid polymers, nu­ cleic acids and haptens. On the other hand. until recently there has been very little information on protein antigens. The complexity of these molecules posed an immense chemical obstacle to precise immuno­ chemical analysis. Indeed, it is this difficulty with proteins that spurred the synthesis and immunological studies of amino acid poly­ mers. The control and normal regulation of the immune system at the cellular-molecular interface and the great majority of antigens asso­ ciated with immune disorders are attributed to protein molecules. In the last few years great advances have been made in the analysis and synthesis of the antigenic sites of some proteins. The entire antigenic structures of myoglobin and lysozyme and the partial anti­ genic structures of several other proteins have been determined. Moreover, in the past seven years several biological responses resulting from the reactions of proteins and their peptides with cells of the immune system were described.

Keywords

antibody antigen immune system immunobiology immunology proteins

Editors and affiliations

  • M. Z. Atassi
    • 1
    • 2
  • A. B. Stavitsky
    • 3
  1. 1.Mayo Medical SchoolRochesterUSA
  2. 2.University of MinnesotaMinneapolisUSA
  3. 3.School of MedicineCase Western Reserve UniversityClevelandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-8858-0
  • Copyright Information Springer-Verlag US 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-8860-3
  • Online ISBN 978-1-4615-8858-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site