Advances in Neurochemistry

Volume 3

  • B. W. Agranoff
  • M. H. Aprison

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Neil Raymond Sims, Patrick Robert Carnegie
    Pages 1-41
  3. Lawrence F. Eng, John W. Bigbee
    Pages 43-98
  4. Sahebarao P. Mahadik, Hadassah Tamir, Maurice M. Rapport
    Pages 99-163
  5. Richard P. Shank, Lewis T. Graham Jr.
    Pages 165-201
  6. Back Matter
    Pages 295-304

About this book

Introduction

The original premise of the Editors in initiating this series was that there existed a readership ofneurochemists with considerable biochemical back­ ground who would make use of a series dedicated to both new develop­ ments and specialized reviews in neurochemistry. Having selected our authors, we have offered them virtually complete freedom to reflect and speculate in a field in which they have achieved prominence. The response to the first two volumes has been rewarding. The present one continues in this tradition. While we have not attempted to publish specialized volumes, the present volume contains two somewhat related chapters (Chapters 4 and 5, on the role of amino acid neurotransmitters). The first three chapters examine three diverse approaches, each of current interest, in neurochemi­ cal approaches to the molecular bases of neuronal and glial structure. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Need for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Comparison of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Association of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. Historical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 3. Development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 4. Mutant Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 5. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. 11 4. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 5. 3. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. Properties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords

adenosine liberty myelin nervous system neurochemistry spinal cord tumor

Editors and affiliations

  • B. W. Agranoff
    • 1
  • M. H. Aprison
    • 2
  1. 1.Mental Health Research Institute and Department of Biological ChemistryUniversity of MichiganAnn ArborUSA
  2. 2.Institute of Psychiatric Research and Department of Psychiatry and BiochemistryIndiana University School of MedicineIndianapolisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-8240-3
  • Copyright Information Springer-Verlag US 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-8242-7
  • Online ISBN 978-1-4615-8240-3
  • About this book