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Gene Transfer in the Cardiovascular System

Experimental Approaches and Therapeutic Implications

  • Book
  • © 1997

Overview

Editors:
  1. Keith L. March

    1. Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, USA
      R. L. Roudebush VA Medical Center, Indianapolis, USA

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 189)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xx
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  2. Vectors and Gene Transfer Systems: Molecular Aspects of Delivery

    1. Front Matter

      Pages 1-1
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    2. Development of Viral Vectors for Human Gene Therapy: Retrovirus and Adenovirus (Part I)

      • Bruce C. Trapnell, Michael N. Pensiero
      Pages 3-24

    3. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses

      • J. F. Dedieu, E. Vigne, C. Orsini, P. Denefle, M. Perricaudet, P. Yeh
      Pages 25-55

    4. Adeno-Associated Virus and Other New DNA Virus Vectors

      • Terence R. Flotte, Sandra A. Afione, Barry J. Byrne, B. Helen
      Pages 57-83

    5. Plasmid and Other Non-Viral Vectors

      • Linda B. Jacobsen
      Pages 85-110

    6. The HVJ-Liposome Molecular Delivery System for In Vivo Genetic Engineering

      • Gary H. Gibbons
      Pages 111-141

    7. Endogenous Expression Modification: Antisense Approaches

      • Michael Simons
      Pages 143-175

  3. Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery

    1. Front Matter

      Pages 177-177
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    2. Catheter Based Local Drug and Gene Delivery

      • Robert L. Wilensky
      Pages 179-199

    3. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization

      • Charles R. Lambert, Stephen Rowland
      Pages 201-217

    4. Targeted and Sustained-Release Delivery Concepts in Gene Therapy

      • Robert W. Schroff, Lawrence L. Kunz
      Pages 219-236

  4. Gene Delivery for Local Vascular Expression

    1. Front Matter

      Pages 237-237
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    2. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications

      • Elizabeth G. Nabel
      Pages 239-253

    3. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers

      • James Burke, John Ojeifo, James A. Zwiebel
      Pages 255-278

    4. Cell — Based Gene Delivery: Smooth Muscle Cells as Carriers

      • Alexander W. Clowes
      Pages 279-292

    5. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis

      • Robert S. Schwartz, Aloysius Chu, Myung Ho Jeong, Michael E. Staab, Sanjay S. Srivatsa, Vincent J. Pompili et al.
      Pages 293-306

    6. Angiogenesis and Collateral Formation

      • Jeffrey M. Isner
      Pages 307-330

  5. Gene Delivery for Local Cardiac Expression

    1. Front Matter

      Pages 331-331
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    2. Cell-Based Myocardial Protein Delivery

      • Mark H. Soonpaa, Loren J. Field
      Pages 333-353
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Keywords

About this book

The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.

Editors and Affiliations

  • Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, USA

    Keith L. March

  • R. L. Roudebush VA Medical Center, Indianapolis, USA

    Keith L. March

Bibliographic Information

  • Book Title: Gene Transfer in the Cardiovascular System

  • Book Subtitle: Experimental Approaches and Therapeutic Implications

  • Editors: Keith L. March

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-6277-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1997

  • Hardcover ISBN: 978-0-7923-9859-2Published: 31 March 1997

  • Softcover ISBN: 978-1-4613-7881-5Published: 12 October 2012

  • eBook ISBN: 978-1-4615-6277-1Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XX, 516

  • Topics: Cardiology, Human Genetics

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