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The Fate of the Male Germ Cell

  • Book
  • © 1997


Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 424)

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About this book

THE FASCINATION The male germ cell is the only cell of the human organism that leaves the body when it has achieved its final, highly sophisticated structure and properties. The male germ cell is designed for one purpose only: to reach the female gametes and to fertilize them. The various stages in the development of the male germ cell are characterized by proliferative phases, by the recombination of the maternal and paternal chromosomes, and by the differentiation and development of a specialized transport vehicle, the spermato­ zoon. Furthermore, the establishment of a special pool of stem cells, the spermatogonia, guarantees the continuity of the sperm-generation process from puberty to old age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ cell is determined by a program that we know only in fragments. On the one hand every human male is able to produce many billions of germ cells in his lifetime, yet the chance of any single sperm reaching and fertilizing the female germ cell is exceedingly rare. A fertility disturbance means that somewhere during the complicated playing out of the germ cell program mistakes are made, and the program fails. It is still a fact that more than 50% of men presenting with male factor infertility have to be diagnosed as idiopathic, largely because of our lack of knowledge and conse­ quent lack of appropriate diagnostic tools.

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Table of contents (54 chapters)

  1. Human Reproduction

  2. Genes,Chromosomes,and Fertility

  3. Germ Cell Differentiation and Tumorigenesis

  4. The Role of the Testicular Accessory Cells

Editors and Affiliations

  • Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, Germany

    Richard Ivell

  • Anatomical Institute, University of Hamburg, Hamburg, Germany

    Adolf-Friedrich Holstein

Bibliographic Information

  • Book Title: The Fate of the Male Germ Cell

  • Editors: Richard Ivell, Adolf-Friedrich Holstein

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI:

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1997

  • Hardcover ISBN: 978-0-306-45696-1Published: 31 October 1997

  • Softcover ISBN: 978-1-4613-7711-5Published: 28 October 2012

  • eBook ISBN: 978-1-4615-5913-9Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 332

  • Topics: Human Genetics, Veterinary Medicine/Veterinary Science

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