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Theoretical and Computational Methods in Genome Research

  • Sándor Suhai

Table of contents

  1. Front Matter
    Pages i-ix
  2. Pierre Baldi, Søren Brunak, Yves Chauvin, Anders Krogh
    Pages 15-32
  3. Jörg Langowski, Lutz Ehrlich, Markus Hammermann, Christian Münkel, Gero Wedemann
    Pages 57-72
  4. Eugene W. Myers, James L. Weber
    Pages 73-89
  5. Temple F. Smith, R. Mark Adams, Sudeshna Das, Lihua Yu, Loredana Lo Conte, James White
    Pages 91-104
  6. Stephen P. Bryant, Anastassia Spiridou, Nigel K. Spurr
    Pages 117-134
  7. Robert W. Cottingham Jr., Margaret Gelder Ehm, Marek Kimmel
    Pages 135-143
  8. Jeffrey R. O’Connell, Daniel E. Weeks
    Pages 153-160
  9. Victor M. Markowitz, I-Min A. Chen, Anthony S. Kosky
    Pages 161-176
  10. Otto Ritter
    Pages 177-184
  11. David B. Searls
    Pages 185-204
  12. Karl Aberer, Klemens Hemm, Manfred Hendlich
    Pages 205-230
  13. Hans Frauenfelder, Peter G. Wolynes
    Pages 231-236
  14. Maciej Geller, Joanna Trylska, Jan Antosiewicz
    Pages 237-254
  15. K. J. Jalkanen, S. Suhai, H. Bohr
    Pages 255-277
  16. Mats Eriksson, Lennart Nilsson
    Pages 279-286
  17. Kurt Giles, Mia L. Raves, Israel Silman, Joel L. Sussman
    Pages 303-315
  18. Back Matter
    Pages 329-330

About this book

Introduction

The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transcends boundaries tradi­ tionally separating genetics, biology, mathematics, physics, and computer science. Com­ puters have, of course, been intensively used in the field of life sciences for many years, even before genome research started, to store and analyze DNA or protein sequences; to explore and model the three-dimensional structure, the dynamics, and the function of biopolymers; to compute genetic linkage or evolutionary processes; and more. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function ofgenomes ofhigher organisms, has generated, how­ ever, not only a huge and exponentially increasing body of data but also a new class of scientific questions. The nature and complexity of these questions will also require, be­ yond establishing a new kind ofalliance between experimental and theoretical disciplines, the development of new generations both in computer software and hardware technolo­ gies. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can attack with suc­ cess. Many of us still feel that computational models rationalizing experimental findings in genome research fulfill their promises more slowly than desired. There is also an uncer­ tainty concerning the real position of a "theoretical genome research" in the network of established disciplines integrating their efforts in this field.

Keywords

DNA computational models development genes molecular biology protein sequence transcription

Editors and affiliations

  • Sándor Suhai
    • 1
  1. 1.German Cancer Research CenterHeidelbergGermany

Bibliographic information