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  • Book
  • © 1998

Angiotensin II Receptor Blockade Physiological and Clinical Implications

Editors:

  1. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  2. Peter Zahradka

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  3. Ian M. C. Dixon

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  4. Robert E. Beamish

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Progress in Experimental Cardiology (PREC, volume 2)

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Table of contents (42 chapters)

  1. Angiotensin Blockade and Cardiovascular Disease

    2. Influence of AT1 Receptor Inhibition on Cardiac Function and Structure of Diabetic Rats

      • Peter Rösen, Carsten Hönack, Karsten Müssig, Wilhelm Bloch, Klaus Addicks
      Pages 245-260

    3. Role of Myocardial Tissue Angiotensin (Ang) II in Cardiac Pathology

      • J.C. Khatter, M. Paskvalin, M. Ha, S.D. Seth, S.B. Lal
      Pages 261-266

  2. Angiotensin Blockade and Cardiac Hypertrophy and Heart Failure

    1. Front Matter

      Pages 267-267
      PDF

    3. Role of Renin-Angiotensin System in Cardiac Hypertrophy and Failure

      • Qiming Shao, Vincenzo Panagia, Robert E. Beamish, Naranjan S. Dhalla
      Pages 283-310

    6. The Site of Angiotensin Generatlon: Focus on the Heart

      • Larissa M. De Lannoy, A.H. Jan Danser
      Pages 345-355

    9. Angiotensin II Stimulates Contractility and C-Fos Gene Expression in Isolated Atrial Human Myocardium

      • Stephan Wiese, Stephan Schmidt-Schweda, Ernst-Martin Füchtbauer, Friedhelm Beyersdorf, Christian Holubarsch
      Pages 385-394

    10. Stimulatlon of the Na+/Ca2+ Exchanger by Angiotensin II

      • Cherry Ballard-Croft, Stephen Schaffer
      Pages 395-402

    11. Developmental Regulatlon of the Cardiac Renin-Angiotensin System: Expression and Associatlon With Growth and Apoptosis

      • David E. Dostal, Rachel A. Hunt, Chris E. Kule, Kenneth M. Baker
      Pages 403-414

    12. Angiotensin II Regulated Apoptosis in Cardiovascular Remodeling

      • Masatsugu Horiuchi, Hiroyuki Yamada, Masahiro Akishita, Victor J Dzau
      Pages 415-421

  3. Angiotensin Blockade and Remodeling of Heart In Myocardial Infarction

    1. Front Matter

      Pages 435-435
      PDF

    4. Losartan Pretreatment Inhibits an Early Activation of Matrix Metalloproteinases in Acute Myocardial Infarction

      • Naoki Makino, Kazuhiro Masutomo, Shoji Ohtsuka, Masahiro Sugano, Masahiko Nozaki, Hirosuke Matsui et al.
      Pages 459-469
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About this book

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio­ tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.
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Keywords

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Editors and Affiliations

  • Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla, Peter Zahradka, Ian M. C. Dixon, Robert E. Beamish

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Bibliographic Information

  • Book Title: Angiotensin II Receptor Blockade Physiological and Clinical Implications

  • Editors: Naranjan S. Dhalla, Peter Zahradka, Ian M. C. Dixon, Robert E. Beamish

  • Series Title: Progress in Experimental Cardiology

  • DOI: https://doi.org/10.1007/978-1-4615-5743-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-7923-8147-1Published: 31 October 1998

  • Softcover ISBN: 978-1-4613-7631-6Published: 13 October 2012

  • eBook ISBN: 978-1-4615-5743-2Published: 06 December 2012

  • Series ISSN: 1389-1774

  • Edition Number: 1

  • Number of Pages: XLIII, 588

  • Topics: Cardiology

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Buy it now

eBook USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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