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Aspartic Proteinases

Retroviral and Cellular Enzymes

  • Book
  • © 1998

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Editors:
  1. Michael N. G. James

    1. University of Alberta, Edmonton, Canada

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 436)

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About this book

The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak­ ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con­ tributed poster presentations that spanned the whole range of interest in aspartic proteinases.

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Table of contents (65 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Plenary

    1. The Aspartic Proteinases

      • Tom L. Blundell, Kunchur Guruprasad, Armando Albert, Mark Williams, Bancinyane L. Sibanda, Venugopal Dhanaraj
      Pages 1-13

  3. Retroviral Aspartic Proteinases I

    1. The Regulation of Sequential Processing of HIV-1 Gag by the Viral Protease

      • Steve C. Pettit, Nijing Sheng, Radonna Tritch, Susan Erickson-Viitanen, Ronald Swanstrom
      Pages 15-25

    2. A Cellular Anti-Apoptosis Protein is Cleaved by the HIV-1 Protease

      • Bruce D. Korant, Peter Strack, Michelle W. Frey, Christopher J. Rizzo
      Pages 27-29

    3. Engineering Catalytically Defective Forms of HIV Protease to Modulate Its Activity

      • Charles S. Craik, Lilia M. Babé, Deborah Dauber, Fiona McPhee, Jason Rosé, Ayce Ãœnal
      Pages 31-39

    4. The Aspartic Proteinase from Equine Infectious Anaemia Virus

      • D. J. Powell, D. Bur, A. Wlodawer, A. Gustchina, B. M. Dunn, J. Kay
      Pages 41-45

    5. The Effect of Substrates on the Kinetics and the in Vivo Threshold Activity of Mutant HIV-1 Proteases

      • Jacques Ermolieff, Xinli Lin, Jordan Tang
      Pages 47-51

    6. A Comparison of gag—pol Precursor Cleavage in Naturally Arising HIV Variants

      • Gregory Bloom, Elena Perez, Shefal Parikh, John Kay, John Mills, Maureen Goodenow et al.
      Pages 53-57

    7. X-Ray Crystallographic Studies of the Structure-Function Relationships of HIV-1 Protease

      • Lin Hong, Cai Zhang, Jean A. Hartsuck, Steve Foundling, Jordan Tang
      Pages 59-63

    8. Optimization of a Macromolecular Inhibitor of HIV-1 Protease

      • Deborah S. Dauber, Fiona McPhee, Ayçe Ãœnal, Charles S. Craik
      Pages 65-70

  4. Back Matter

    Pages 71-74
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  5. Retroviral Aspartic Proteinases II

    1. In Vitro Selection and Characterization of VX-478 Resistant HIV-1 Variants

      • S. Pazhanisamy, Judith A. Partaledis, B. G. Rao, David J. Livingston
      Pages 75-83

    2. Sensitivity to Inhibition and Catalytic Efficiency of HIV Proteinase Mutants

      • S. I. Wilson, L. H. Phylip, S. V. Gulnik, J. S. Mills, D. Bur, B. M. Dunn et al.
      Pages 85-89

    3. Computer Assisted Evaluation of Inhibitor Sensitivity to HIV-1 PR Mutants

      • Fredy Sussman, Luis A. Martínez, M. Carmen Villaverde
      Pages 91-97

    4. Investigation of an Allosteric Site of HIV-1 Proteinase Involved in Inhibition by Cu2+

      • Helena Danielson, Maria T. Lindgren, Per-Olof Markgren, Ulrika Nillroth
      Pages 99-103

    5. Analysis of Autoprocessing of Mason-Pfizer Monkey Virus Proteinase in Vitro

      • Iva Pichová, AleÅ¡ Zábranský, Iveta Košťálová, Olga HruÅ¡ková-Heidingsfeldová, Martin Andreansky, Eric Hunter et al.
      Pages 105-108

    6. Subsequent Selfprocessing of Bovine Leukemia Virus Proteinase in Vitro

      • Iva Pichová, Anna Teplitsky, Romana Cubínková, AleÅ¡ Zábranský, Gil Shoham, Olga HruÅ¡ková-Heidingsfeldová
      Pages 109-113

    7. Mechanism of Action of Aspartic Proteases

      • I. V. Kashparov, M. E. Popov, E. M. Popov
      Pages 115-121

    8. Theory and Method of a Priori Computation of Catalytic Acts of Aspartic and Serine Proteinases

      • M. E. Popov, I. V. Kashparov, E. M. Popov
      Pages 123-126

  6. Back Matter

    Pages 127-132
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Editors and Affiliations

  • University of Alberta, Edmonton, Canada

    Michael N. G. James

Bibliographic Information

  • Book Title: Aspartic Proteinases

  • Book Subtitle: Retroviral and Cellular Enzymes

  • Editors: Michael N. G. James

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-5373-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1998

  • Hardcover ISBN: 978-0-306-45809-5Published: 31 March 1998

  • Softcover ISBN: 978-1-4613-7452-7Published: 17 October 2012

  • eBook ISBN: 978-1-4615-5373-1Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 499

  • Topics: Animal Anatomy / Morphology / Histology, Plant Sciences, Human Genetics

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