Advances in Allogeneic Hematopoietic Stem Cell Transplantation

  • Richard K. Burt
  • Mary M. Brush

Part of the Cancer Treatment and Research book series (CTAR, volume 101)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ann E. Woolfrey, Claudio Anasetti, Effie W. Petersdorf, Paul J. Martin, Jean E. Sanders, John A. Hansen
    Pages 25-51
  3. P. Jean Henslee-Downey
    Pages 53-77
  4. E. Gluckman, V. Rocha, C. L. Chastang
    Pages 79-96
  5. Sergio Giralt, Issa Khouri, Richard Champlin
    Pages 97-108
  6. Norma S. Kenyon, Maria Chatzipetrou, Andreas Tzakis, Joshua Miller, Rodolfo Alejandro, Camillo Ricordi
    Pages 109-132
  7. Naoto T. Ueno, Gabriel N. Hortobagyi, Richard E. Champlin
    Pages 133-156
  8. Kenneth G. Lucas, J. Christian Barrett
    Pages 203-232
  9. D. N. J. Hart, G. J. Clark
    Pages 283-310
  10. James L. M. Ferrara, Ernst Holler, Bruce Blazar
    Pages 331-368
  11. Charles J. Link Jr., Ann Traynor, Tatiana Seregina, Richard K. Burt
    Pages 369-375
  12. Stephen G. Emerson, Patricia D. Conrad.
    Pages 377-388
  13. Ian K. McNiece
    Pages 389-405
  14. Back Matter
    Pages 407-414

About this book

Introduction

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Keywords

cancer cell cell culture chemotherapy clinical trial cytokines hematopoietic stem cell hematopoietic stem cell transplantation immunotherapy leukemia lymphocytes stem cell stem cell transplantation transplantation tumor

Editors and affiliations

  • Richard K. Burt
    • 1
  • Mary M. Brush
    • 1
  1. 1.Northwestern University Medical CenterChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-4987-1
  • Copyright Information Kluwer Academic Publishers 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7264-6
  • Online ISBN 978-1-4615-4987-1
  • Series Print ISSN 0927-3042
  • About this book