Protein Dynamics, Function, and Design

  • Oleg Jardetzky
  • Jean-François Lefèvre
  • Robin E. Holbrook

Part of the NATO ASI Series book series (NSSA, volume 301)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Angela M. Gronenborn, G. Marius Clore
    Pages 1-13
  3. Jeffrey C. Hoch, Alan S. Stern, Peter J. Connolly
    Pages 15-26
  4. William N. Lipscomb
    Pages 27-35
  5. Kenneth E. Prehoda, Ed S. Mooberry, John L. Markley
    Pages 59-86
  6. Hans Frauenfelder
    Pages 95-102
  7. Oleg Jardetzky
    Pages 103-128
  8. R. Andrew Atkinson, Jean-François Lefèvre
    Pages 129-145
  9. Leo Spyracopoulos, Stéphane M. Gagné, Wolfram Gronwald, Lewis E. Kay, Brian D. Sykes
    Pages 147-162
  10. Kevin W. Plaxco, Christopher M. Dobson
    Pages 163-172
  11. Satoko Yoshizawa, Joseph D. Puglisi
    Pages 173-182
  12. Back Matter
    Pages 183-222

About this book

Introduction

This volume is a collection of articles from the proceedings of the International School of Structural Biology and Magnetic Resonance 3rd Course: Protein Dynamics, Function, and Design. This NATO Advance Study Institute was held in Erice at the Ettore Majorana Centre for Scientific Culture on April 16-28, 1997. The aim of the Institute was to bring together experts applyipg different physical methods to problems of macro­ molecular dynamics-notably x-ray diffraction, NMR and other forms of spectroscopy, and molecular dynamics simulations. Emphasis was placed on those systems and types of problems-such as mechanisms of allosteric control, signal transmission, induced fit to different ligands with its implications for drug design, and the effects of dynamics on structure determination-where a correlation of findings obtained by different methods could shed the most light on the mechanisms involved and stimulate the search for new approaches. The individual articles represent the state of the art in each of the areas cov­ ered and provide a guide to the original literature in this rapidly developing field. v CONTENTS 1. Determining Structures of ProteinlDN A Complexes by NMR Angela M. Gronenbom and G. Marius Clore 2. Fitting Protein Structures to Experimental Data: Lessons from before Your Mother Was Born . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Jeffrey C. Hoch, Alan S. Stem, and Peter J. Connolly 3. Multisubunit Allosteric Proteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 William N. Lipscomb 4. Studying Protein Structure and Function by Directed Evolution: Examples with Engineered Antibodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Andreas Pliickthun 5. High Pressure Effects on Protein Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords

Calcium DNA biophysical techniques pressure effects protein structure proteins

Editors and affiliations

  • Oleg Jardetzky
    • 1
  • Jean-François Lefèvre
    • 2
  • Robin E. Holbrook
    • 1
  1. 1.Stanford UniversityStanfordUSA
  2. 2.Université Louis PasteurIllkirch GraffenstadenFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-4895-9
  • Copyright Information Plenum Press, New York 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7219-6
  • Online ISBN 978-1-4615-4895-9
  • About this book