Cell and Molecular Biology of the Ear

1. Front Matter

   Pages i-xviii

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2. Mechanoreceptor Biology

   1. Front Matter

      Pages 1-1

      PDF

   2. Kinociliary Mechanoreceptors in the Equilibrium Receptor Organs of Cephalopods

      • Bernd U. Budelmann

      Pages 3-17

   3. Stereocilia Based Mechanoreceptors of Sea Anemones

      • Glen M. Watson, Patricia Mire

      Pages 19-39

   4. Plasma Membrane Ca2+-ATPase and Hair-Cell Function

      • Rachel A. Dumont, Peter G. Gillespie

      Pages 41-54

   5. Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes

      • Dhasakumar S. Navaratnam, J. Carl Oberholtzer

      Pages 55-68

   6. Structural Basis of Outer Hair Cell Motility or Where’s the Motor?

      • W. E. Brownell, J. S. Oghalai

      Pages 69-83

3. Developmental Biology of the Ear

   1. Front Matter

      Pages 85-85

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   2. Induction of Ectodermal Placodes

      • Clare V. H. Baker, Andrew K. Groves, Michael R. Stark, Marianne Bronner-Fraser

      Pages 87-97

   3. Compartments and Boundaries in the Developing Inner Ear

      • Donna M. Fekete, Xiaoying Gao

      Pages 99-112

   4. Role of the POU-Domain Transcription Factor Brn-3.1 in Hair Cell Development

      • Allen F. Ryan

      Pages 113-119

4. Genes and Deafness

   1. Front Matter

      Pages 121-121

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   2. Genetic Linkage Studies of Hereditary Hearing Loss

      • W. J. Kimberling

      Pages 123-132

   3. Mitochondrial Mutations and Hearing Loss

      • Nathan Fischel-Ghodsian

      Pages 133-144

   4. Loss and Regeneration of Cochlear Hair Cell Innervation Following Sound and Drug Damage

      • Douglas A. Cotanche, Anne K. Hennig

      Pages 145-155

   5. Mechanism and Prevention of Aminoglycoside-Induced Hearing Loss

      • Su-Hua Sha, Jochen Schacht

      Pages 157-164

   6. Neurotrophic Signaling by Membrane Electrical Activity in Spiral Ganglion Neurons

      • Steven H. Green

      Pages 165-182

   7. Protection of Cochlear Hair Cells from Gentamicin Ototoxicity and Mechanisms of Mammalian Hair Cell Regeneration in Vitro

      • Wei-Qiang Gao

      Pages 183-197

   8. Protection and Regeneration of Vestibular Hair Cells—the Role of Neurotrophins after Gentamicin Ototoxicity

      • V. Honrubia, I. Lopez, S. C. Lee, G. Li, W. H. Chung, K. Beykirch et al.

      Pages 199-213

5. Gene-Based Therapy for Sensorineural Hearing Loss

   1. Front Matter

      Pages 215-215

      PDF

Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946. Two grateful patients of Dr. House put forth the idea that his knowledge and innovative skills could be used to expand the understanding of hearing impairment and its treatment. Those two early patients provided the "seed money" to begin the Institute. Since that time, the growth has been phenomenal­ from a one-man laboratory to a multidisciplinary facility boasting over 175 scien­ tists, physicians, and support staff, all dedicated to the advancement of otologic research and education. Six years ago after a half-century of remarkable success with prosthetic and device research, the Institute began cultivating a new field of endeavor-cell and molecular biology. Don Nielsen, then the Institute's Executive Vice President for Research and Scientific Director, began exploring the potential for hair cell regen­ eration and presented his ideas to the Board of Trustees. For a period of six months, we did a lot of fact finding to assess what role the Institute might take in this excit­ ing new field.

• ATPase
• cells
• gene therapy
• gene transfer
• genes
• genetics
• molecular biology

• House Ear Institute, Los Angeles, USA

  David J. Lim

Policies and ethics