The Paramyxoviruses

  • David W. Kingsbury

Part of the The Viruses book series (VIRS)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Craig R. Pringle
    Pages 1-39
  3. Mark S. Galinski, Steven L. Wechsler
    Pages 41-82
  4. Thomas Barrett, Shaila M. Subbarao, Graham J. Belsham, Brian W. J. Mahy
    Pages 83-102
  5. Robert A. Lamb, Reay G. Paterson
    Pages 181-214
  6. Daniel Kolakofsky, Sylvia Vidal, Joseph Curran
    Pages 215-233
  7. Benjamin M. Blumberg, John Chan, Stephen A. Udem
    Pages 235-247
  8. Gian Guido Re
    Pages 275-298
  9. R. E. Randall, W. C. Russell
    Pages 299-321
  10. Wayne M. Sullender, Gail W. Wertz
    Pages 383-406
  11. Mark E. Peeples
    Pages 427-456
  12. Ranjit Ray, Laurent Roux, Richard W. Compans
    Pages 457-479
  13. Erling Norrby
    Pages 481-507
  14. Francis L. Black
    Pages 509-536

About this book

Introduction

What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur­ poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil­ lions annually. There are many pathogenic paramyxoviruses and too few effec­ tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin­ sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.

Keywords

RNA development protein transcription virus

Editors and affiliations

  • David W. Kingsbury
    • 1
  1. 1.Howard Hughes Medical InstituteBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3790-8
  • Copyright Information Plenum Press, New York 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6689-8
  • Online ISBN 978-1-4615-3790-8
  • About this book