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DNA Polymorphisms as Disease Markers

  • D. J. Galton
  • G. Assmann

Part of the NATO ASI Series book series (NSSA, volume 214)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Theoretical Background

  3. Diabetes

  4. Lipids

    1. Gerd Assmann, Arnold von Eckardstein, Harald Funke
      Pages 61-70
    2. Louis M. Havekes, Arn M. J. M. van den Maagdenberg, Peter de Knijff, Monique Mulder, Rune R. Frants
      Pages 71-77
    3. Alberto Corsini, Alberico L. Catapano, Maria Mazzotti, Guido Franceschini, Cesare Romano, Remo Fumagalli et al.
      Pages 79-89
    4. Detlev Ameis, Junji Kobayashi, Heiner Greten, Michael C. Schotz
      Pages 105-109
  5. Atherosclerosis

    1. J. C. Chamberlain, D. J. Galton
      Pages 123-133
    2. William H. Price, Arthur H. Kitchin
      Pages 135-147
    3. David J. Galton, John C. Alcolado
      Pages 149-155
  6. Back Matter
    Pages 157-160

About this book

Introduction

The purpose of this workshop was to assess the value of DNA polymorphisms for the prediction, diagnosis or elucidation of aetiology for common metabolic diseases such as diabetes, hyperlipidaemia and atherosclerosis. The advent of recombinant DNA techniques has produced an explosion in knowledge of restriction site polymorphisms and hypervariable sequences around candidate genes for such common metabolic diseases as atherosclerosis, hyperlipidaemia and diabetes mellitus. These diseases are the major causes of morbidity and mortality in Western societies today. Since 1983 it has become apparent that there is much more variation in the frequency and sites of these DNA polymorphisms in human populations than was initially appreciated and that the majority of these DNA polymorphisms are only linkage markers for the disease. Consequently it was considered timely for laboratories involved in the mapping of these DNA mutations to meet together to discuss the implications of their studies. The main issues are whether such DNA polymorphisms will lead to an identification of major aetiological loci and which are the best techniques to achieve this? What is the cause of the differences in frequencies of such polymorphisms amongst world populations? Are such studies best conducted in homogeneous populations or in pedigrees? Are haplotypes, though more laborious to construct, a better way to proceed than analysis of single site polymorphisms? What are the consensus polymorphic sites that relate to the common metabolic diseases of diabetes, atherosclerosis and the hyperlipidaemias? The real need now to discuss the theoretical background behind the

Keywords

DNA Lipid atherosclerosis coronary heart disease genes genetics heart heart disease high-density lipoprotein (HDL) lipoprotein metabolism molecular genetics mutation protein

Editors and affiliations

  • D. J. Galton
    • 1
  • G. Assmann
    • 2
  1. 1.Department of MedicineSt. Bartholomew’s HospitalLondonUK
  2. 2.Zentrallaboratorien der Medizinische EinrichtungenUniversity of MunsterGermany

Bibliographic information