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Thrombin

Structure and Function

  • Lawrence J. Berliner

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Structure

    1. Front Matter
      Pages 1-1
    2. Wolfram Bode, Robert Huber, Timothy J. Rydel, Alexander Tulinsky
      Pages 3-61
  3. Biochemistry

    1. Front Matter
      Pages 115-115
    2. James C. Powers, Chih-Min Kam
      Pages 117-158
    3. Steven T. Olson, Ingemar Björk
      Pages 159-217
    4. Stuart R. Stone, John M. Maraganore
      Pages 219-256
    5. L. Lorand, J. T. Radek
      Pages 257-271
  4. Physiology

    1. Front Matter
      Pages 273-273
    2. Rachel Bar-Shavit, Miriam Benezra, Valerie Sabbah, Elisabetta Dejana, Israel Vlodavsky, George D. Wilner
      Pages 315-350
    3. Joe G. N. Garcia, Judy L. Aschner, Asrar B. Malik
      Pages 397-430
  5. Back Matter
    Pages 431-438

About this book

Introduction

Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three­ dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start­ ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem­ istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com­ plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.

Keywords

Peptide X-ray biochemistry endothelium magnetic resonance physiology

Editors and affiliations

  • Lawrence J. Berliner
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

Bibliographic information