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Emerging Targets in Antibacterial and Antifungal Chemotherapy

  • Joyce A. Sutcliffe
  • Nafsika H. Georgopapadakou

Table of contents

  1. Front Matter
    Pages i-xv
  2. Antibacterial Chemotherapy

    1. Front Matter
      Pages N1-N1
    2. Charles S. McHenry
      Pages 37-67
    3. Asis Das, Joseph DeVito, Jason Sparkowski, Frederick Warren
      Pages 68-116
    4. Joe Lutkenhaus
      Pages 117-150
    5. Suzanne Jackowski
      Pages 151-162
    6. Rajeev Misra, Thomas J. Silhavy
      Pages 163-175
    7. Francis C. Neuhaus, Nafsika Georgopapadakou
      Pages 205-273
    8. Jack Coleman
      Pages 274-291
    9. Sarah K. Highlander, George M. Weinstock
      Pages 323-346
  3. Antifungal Chemotherapy

    1. Front Matter
      Pages 347-347
    2. David E. Jackson, D. P. Figgitt, Stephen P. Denyer
      Pages 374-392
    3. Leo W. Parks, R. Todd Lorenz, Warren M. Casey
      Pages 393-409
    4. Keith Barrett-Bee, Neil Ryder
      Pages 410-436
    5. A. C. Oehlschlager, Eva Czyzewska
      Pages 437-475
    6. N. H. Georgopapadakou
      Pages 476-494
    7. Richard A. Calderone, Makiko Fukayama
      Pages 524-545
    8. John F. Ryley, Keith Barrett-Bee
      Pages 546-567
    9. Gregg Y. Lipschik, Joseph A. Kovacs
      Pages 568-588
  4. Back Matter
    Pages 589-606

About this book

Introduction

Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.

Keywords

DNA Lipid RNA enzymes lead proteins

Editors and affiliations

  • Joyce A. Sutcliffe
  • Nafsika H. Georgopapadakou
    • 1
  1. 1.Department of Chemotherapy (58/2)Roche Research CenterNutleyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3274-3
  • Copyright Information Routledge, Chapman & Hall, Inc. 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6440-5
  • Online ISBN 978-1-4615-3274-3
  • Buy this book on publisher's site