Overview
- Editors:
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Mauro Magnani
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University of Urbino, Urbino, Italy
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John R. DeLoach
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Agricultural Research Service Food Animal Protection Research Laboratory, United States Department of Agriculture, College Station, USA
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Table of contents (42 chapters)
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Front Matter
Pages i-xiii
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On Red Blood Cells, Hemolysis and Resealed Ghosts
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Methods and Procedures for Preparing Resealed Erythrocytes
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- Andrea Mosca, Renata Paleari, Vincenzo Russo, Enrico Rosti, Rita Nano, Andrea Boicelli et al.
Pages 19-26
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- Guillemette Bourget, Laurence Boucher, Claude Ropars
Pages 27-33
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- Rita Nano, Andrea Mosca, Renata Paleari, Andrea Boicelli
Pages 35-39
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- Stefania Villa, Fabio Rossi, Pier Antonio Biondi, Vincenzo Russo, Tiziano Crimella, Gemino Fiorelli et al.
Pages 41-49
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- Tiziano Crimella, Stefania Villa, Fabio Rossi, Gemino Fiorelli, Alberto Zanella
Pages 51-54
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- Laura Chiarantini, John R. DeLoach
Pages 55-62
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- Kathleen Andrews, Robert E. Droleskey, Laura Chiarantini, John R. DeLoach
Pages 63-71
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- Robert E. Droleskey, Kathleen Andrews, Laura Chiarantini, John R. DeLoach
Pages 73-80
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- José Luque, Marina I. GarÃn, Silvia Sanz, Paloma Ropero, Montserrat Pinilla
Pages 81-89
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- Maria A. Castellana, Maria R. De Renzis, Giampiero Piccinini, Giampaolo Minetti, Claudio Seppi, Cesare Balduini et al.
Pages 91-99
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- Vincenzo Russo, Robin Barker-Gear, Robert Gates, Robert Franco
Pages 101-107
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Resealed Erythrocytes as a Tool for Basic Studies
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Front Matter
Pages 109-109
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- Marietta Harrison, Chris Isaacson, Prema Rathinavelu, Philip S. Low
Pages 111-117
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- Augusto Accorsi, Elena Piatti, Maria Piera Piacentini, Antonio Fazi
Pages 119-126
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- Robert A. Schlegel, Katherine Lumley-Sapanski, Patrick Williamson
Pages 133-138
About this book
Until recently the only biomedical use of erythrocytes was in transfusion medicine to restore a normal oxygen delivery. The development of a technology that permits one to open and reseal erythrocytes has dramatically changed this perspective. Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. The technology of opening and resealing the erythrocytes has also been used successfully to investigate several basic aspects of erythrocyte metabolism, survival, pathology, etc. Thus, researchers in this field have an extraordinary opportunity to specifically modify the erythrocytes by the introduction of enzymes that generate new metabolic abilities, antibodies that inactivate single metabolic steps, or metabolites that can influence oxygen delivery and/or other cell properties. Furthermore, the pharmacokinetics of any drug can be potentially manipulated by using the erythrocytes as a delivery system. This book, The Use of Resealed Erythrocytes, is based on the fourth meeting of the "International Society for the Use of Resealed Erythrocytes as Carriers and Bioreactors" (I. S. U. R. E. ), held in Urbino, Italy, in 1991, and examines the most recent applications and developments of this technology.
Editors and Affiliations
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University of Urbino, Urbino, Italy
Mauro Magnani
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Agricultural Research Service Food Animal Protection Research Laboratory, United States Department of Agriculture, College Station, USA
John R. DeLoach