The Use of Resealed Erythrocytes as Carriers and Bioreactors

  • Mauro Magnani
  • John R. DeLoach

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 326)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. On Red Blood Cells, Hemolysis and Resealed Ghosts

    1. Front Matter
      Pages 1-1
  3. Methods and Procedures for Preparing Resealed Erythrocytes

    1. Front Matter
      Pages 17-17
    2. Andrea Mosca, Renata Paleari, Vincenzo Russo, Enrico Rosti, Rita Nano, Andrea Boicelli et al.
      Pages 19-26
    3. Rita Nano, Andrea Mosca, Renata Paleari, Andrea Boicelli
      Pages 35-39
    4. Stefania Villa, Fabio Rossi, Pier Antonio Biondi, Vincenzo Russo, Tiziano Crimella, Gemino Fiorelli et al.
      Pages 41-49
    5. Tiziano Crimella, Stefania Villa, Fabio Rossi, Gemino Fiorelli, Alberto Zanella
      Pages 51-54
    6. Kathleen Andrews, Robert E. Droleskey, Laura Chiarantini, John R. DeLoach
      Pages 63-71
    7. Robert E. Droleskey, Kathleen Andrews, Laura Chiarantini, John R. DeLoach
      Pages 73-80
    8. José Luque, Marina I. Garín, Silvia Sanz, Paloma Ropero, Montserrat Pinilla
      Pages 81-89
    9. Maria A. Castellana, Maria R. De Renzis, Giampiero Piccinini, Giampaolo Minetti, Claudio Seppi, Cesare Balduini et al.
      Pages 91-99
  4. Resealed Erythrocytes as a Tool for Basic Studies

    1. Front Matter
      Pages 109-109
    2. Marietta Harrison, Chris Isaacson, Prema Rathinavelu, Philip S. Low
      Pages 111-117
    3. Augusto Accorsi, Elena Piatti, Maria Piera Piacentini, Antonio Fazi
      Pages 119-126
    4. Robert A. Schlegel, Katherine Lumley-Sapanski, Patrick Williamson
      Pages 133-138

About this book

Introduction

Until recently the only biomedical use of erythrocytes was in transfusion medicine to restore a normal oxygen delivery. The development of a technology that permits one to open and reseal erythrocytes has dramatically changed this perspective. Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. The technology of opening and resealing the erythrocytes has also been used successfully to investigate several basic aspects of erythrocyte metabolism, survival, pathology, etc. Thus, researchers in this field have an extraordinary opportunity to specifically modify the erythrocytes by the introduction of enzymes that generate new metabolic abilities, antibodies that inactivate single metabolic steps, or metabolites that can influence oxygen delivery and/or other cell properties. Furthermore, the pharmacokinetics of any drug can be potentially manipulated by using the erythrocytes as a delivery system. This book, The Use of Resealed Erythrocytes, is based on the fourth meeting of the "International Society for the Use of Resealed Erythrocytes as Carriers and Bioreactors" (I. S. U. R. E. ), held in Urbino, Italy, in 1991, and examines the most recent applications and developments of this technology.

Keywords

ATP Antigen Oxidation drug delivery enzymes metabolism

Editors and affiliations

  • Mauro Magnani
    • 1
  • John R. DeLoach
    • 2
  1. 1.University of UrbinoUrbinoItaly
  2. 2.Agricultural Research Service Food Animal Protection Research LaboratoryUnited States Department of AgricultureCollege StationUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3030-5
  • Copyright Information Plenum Press, New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6321-7
  • Online ISBN 978-1-4615-3030-5
  • Series Print ISSN 0065-2598
  • About this book