The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

1. Front Matter

   Pages i-xiv

   PDF

2. Background

   1. Aging, Comorbidity, and Breast Cancer Survival: An Epidemiologic View

      • William A. Satariano

      Pages 1-11

   2. Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm ?

      • Jeanne Mandelblatt

      Pages 13-26

3. Genetics and Epigenetics

   1. Genetic and Molecular Basis for Cellular Senescence

      • J. Carl Barrett, Lois A. Annab, P. Andrew Futreal

      Pages 27-43

   2. A Single Gene Change Can Extend Yeast Life Span: The Role of RAS in Cellular Senescence

      • S. Michal Jazwinski, James B. Chen, Jiayan Sun

      Pages 45-53

   3. A Comparison of the Properties of Human P53 Mutant Alleles

      • Robin S. Quartin, Arnold J. Levine

      Pages 55-65

   4. Gene Structure and Expression in Colorectal Cancer

      • James M. Pipas, Kay Pogue-Geile, Gene G. Finley, Christine A. Cartwright, Arnold I. Meiesler

      Pages 67-75

4. Influence of Physiological Changes in the Immune Constitutions in Aging and Cancer

   1. Tumors and Aging: The Influence of Age-Associated Immune Changes Upon Tumor Growth and Spread

      • William B. Ershler

      Pages 77-92

   2. T Cell Differentiation and Functional Maturation in Aging Mice

      • Marilyn L. Thoman, D. N. Ernst, M. V. Hobbs, W. O. Weigle

      Pages 93-106

5. Molecular Biology of Age-Related Changes in Some Types of Cancer

   1. Breast Cancer

      1. Cytogenetics and Clinical Correlations in Breast Cancer

         • Julia C. Emerson, Sydney E. Salmon, William Dalton, Daniel L. McGee, Jin-Ming Yang, Floyd H. Thompson et al.

         Pages 107-118

      2. Breast Cancer: Influence of Endocrine Hormones, Growth Factors and Genetic Alterations

         • Robert B. Dickson, Michael D. Johnson, Dorraya El-Ashry, Yenian Eric Shi, Mozeena Bano, Gerhard Zugmaier et al.

         Pages 119-141

      3. Regulation of Estrogen Receptor Expression in Breast Cancer

         • Mary Beth Martin, Miguel Saceda, Ralph K. Lindsey

         Pages 143-153

      4. Aging and Development of Ovarian Epithelial Carcinoma: The Relevance of Changes in Ovarian Stromalandrogen Production

         • Margaret A. Thompson, Mark D. Adelson

         Pages 155-165

   2. Breast Cancer

      1. Prostatic Cancer: An Age-Old Problem

         • John T. Isaacs

         Pages 167-184

      2. Stromal — Epithelial Paracrine Interactions in the Neoplastic Rat and Human Prostate

         • Daniel Djakiew, Beth Pflug, Makoto Onoda

         Pages 185-202

      3. Heparin-Binding Fibroblast Growth Factors and Prostate Cancer

         • Wallace L. McKeehan, Jinzhao Hou, Pamela Adams, Fen Wang, Guo-Chen Yan, Mikio Kan

         Pages 203-213

6. Molecular Epidemiology and Treatment Modality in Patients of Different Ages with Leukemias

   1. Age Related Changes in Adults with Acute Leukemia

      • Charles A. Schiffer, O. Ross McIntyre

      Pages 215-229

   2. Significance of Chromosomal Changes in Patients of Different Age Groups with Acute Leukemia

      • Jacqueline Whang-Peng

      Pages 231-239

   3. Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young and Old

      • Javed Ashraf, E. Brad Thompson

      Pages 241-269

7. Drug Resistance

   1. General Aspects of Cancer Chemotherapy in the Aged

      • Ronald A. Fleming, Robert L. Capizzi

      Pages 271-286

Background Cancer is a variety of malignancies generally associated with aging. As the overall health technology and health care delivery improved with the advances made in medicine and science in the United States, the life expectancy of the population also increased. The average life expectancy in the U. S. A. has increased from 49 years at the end of 1900 to 75 years today in 1990 (1-3). The population of 65 years and older that constituted 25. 5 million or 11. 3% of the total U. S. population in 1980(4) has now increased to 31. 1 million or 12. 5% of the population according to the 1990(5) census. As cancer diagnosis and treatment have improved, cancer mortality among patients under 55 has been significantly reduced within recent years *1; however, cancer incidence under 55 is still increasing at about 0. 4% per year (as compared to 1. 0% for all ages or 0. 6% for < 65) according to the 1990 review of the 15 year trends in the Cancer Statistics Review 1973-1987, published by the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI). In contrast, both cancer incidence and mortality have been increasing among the population 65 and over*2 at a rate of 1. 4% and 1. 0% respectively per year between 1973-1987(6).

• Endoplasmatisches Reticulum
• aging
• cancer
• epidemiology
• mortality

• National Cancer Institute, Bethesda, USA

  Stringner Sue Yang

• National Institute on Aging, Bethesda, USA

  Huber R. Warner

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