New Developments in Lipid-Protein Interactions and Receptor Function

  • K. W. A. Wirtz
  • L. Packer
  • J. Å. Gustafsson
  • A. E. Evangelopoulos
  • J. P. Changeux

Part of the NATO ASI Series book series (NSSA, volume 246)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Components of Signal Transduction

    1. Jacopo Meldolesi, Alberto Ciardo, Antonello Villa, Fabio Grohovaz
      Pages 1-6
    2. Ian Batty, A. Nigel Carter, C. Peter Downes, Francisco Estevez, Daniel Sillence, Cyrus Vaziri
      Pages 7-19
    3. Dirk De Valck, Rudi Beyaert, Frans Van Roy, Walter Fiers
      Pages 29-37
    4. Christine Guinebault, Monique Plantavid, Bernard Payrastre, Pascal Grondin, Claire Racaud-Sultan, Gérard Mauco et al.
      Pages 39-44
  3. Receptor Function and Regulation

    1. Wouter Moolenaar, Rob van der Bend, Emile van Corven, Kees Jalink, Thomas Eichholtz, Wim van Blitterswijk
      Pages 55-61
    2. Ron D. M. Soede, Dorien J. M. Peters, Bernd Jastorff, Peter J. M. Van Haastert, Pauline Schaap
      Pages 87-101
    3. Matias A. Avila, Yolanda León, Beatriz Gil, Isabel Varela-Nieto
      Pages 103-113
    4. Cindy C. Gerhardt, Hans J. Lodder, Ellen van Kesteren, Rudi J. Planta, Karel S. Kits, Harm van Heerikhuizen et al.
      Pages 115-128
  4. Transcription Factors and Gene Regulation

    1. Kleanthis G. Xanthopoulos
      Pages 129-137
    2. Denis Masquilier, Brid M. Laoide, Véronique Delmas, Rolf P. de Groot, Nicholas S. Foulkes, Enrico Benusiglio et al.
      Pages 139-152
    3. Ronald M. A. Knegtel, Masato Katahira, Johannes G. Schilthuis, Rolf Boelens, Douglas Eib, Paul T. van der Saag et al.
      Pages 153-168
  5. Biosynthesis, Insertion and function of Membrane Components

  6. Membrane Peroxidation and Protection

  7. Back Matter
    Pages 309-318

About this book


A NATO Advanced Study Institute on "New Developments in Lipid-Protein Interactions and Receptor Function" was held on the Island of Spetsai, Greece, from August 16-27, 1992. This Institute was organized to bring together researchers in the field of membrane organization and dynamics with those actively involved in studies on receptor function, signal transduction mechanisms and gene regulation. 2 Presentations and discussions focussed on the regulation of intracellular Ca +-levels, on the second messengers derived from inositol lipids and on the specific phospholipase C isozymes involved in these processes. A major focus was on G-proteins and the effect of lipid anchors on their function. These principles of regulation were further discussed in the context of receptors for acetylcholine, lysophosphatidic acid and low-density lipoproteins. In addition, various aspects of the genomic regulation of cell growth and differentiation by transcription factors were presented. These topics were put into perspective by discussing the most recent developments in lipid-protein interactions, protein insertion into membranes, membrane lipid organization and lipid dynamics as mediated by phospholipid transfer proteins. This book presents the content of the major lectures and a selection of the most relevant of the most important topics posters. These proceedings offer a comprehensive account presented during the course of the Institute. The book is intended to make these proceedings accessible to a large audience.


Lipid Oxidation biosynthesis cell growth genes proteins signal transduction transcription

Editors and affiliations

  • K. W. A. Wirtz
    • 1
  • L. Packer
    • 2
  • J. Å. Gustafsson
    • 3
  • A. E. Evangelopoulos
    • 4
  • J. P. Changeux
    • 5
  1. 1.University of UtrechtUtrechtThe Netherlands
  2. 2.University of CaliforniaBerkeleyUSA
  3. 3.Karolinska InstituteNOVUMHuddingeSweden
  4. 4.The National Hellenic Research FoundationAthensGreece
  5. 5.Institut PasteurParisFrance

Bibliographic information