ADP-Ribosylation: Metabolic Effects and Regulatory Functions

  • Joel Moss
  • Peter Zahradka

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 12)

Table of contents

  1. Front Matter
    Pages i-2
  2. Historical Perspective

    1. Front Matter
      Pages 3-3
    2. Takashi Sugimura, Masanao Miwa
      Pages 5-12
  3. Poly(ADP-Ribosyl)ation

    1. Front Matter
      Pages 13-13
    2. Gilbert de Murcia, Valérie Schreiber, Miguel Molinete, Bénédicte Saulier, Olivier Poch, Murielle Masson et al.
      Pages 15-24
    3. Rafael Alvarez-Gonzalez, Gustavo Pacheco-Rodriguez, Hilda Mendoza-Alvarez
      Pages 33-37
    4. Shonen Yoshida, Cynthia Marie G. Simbulan
      Pages 39-44
    5. Jean Lagueux, Girish M. Shah, Luc Ménard, Hélène Thomassin, Caroline Duchaine, Christoph Hengartner et al.
      Pages 45-52
    6. Felix R. Althaus, Liane Höfferer, Hanna E. Kleczkowska, Maria Malanga, Hanspeter Naegeli, Phyllis L. Panzeter et al.
      Pages 53-59
    7. Peter Zahradka, Lorraine Yau
      Pages 91-98
    8. Shiao Li Oei, Herbert Herzog, Monica Hirsch-Kauffmann, Rainer Schneider, Bernhard Auer, Manfred Schweiger
      Pages 99-104
  4. Mono(ADP-Ribosylation)

    1. Front Matter
      Pages 105-105
    2. Anna Zolkiewska, Ian J. Okazaki, Joel Moss
      Pages 107-112
    3. Mikako Tsuchiya, Makoto Shimoyama
      Pages 113-118
    4. Tatsuyuki Takada, Ian J. Okazaki, Joel Moss
      Pages 119-122
    5. Wallace J. Iglewski
      Pages 131-133
    6. Tomohiko Maehama, Nobuyuki Sekine, Hiroshi Nishina, Katsunobu Takahashi, Toshiaki Katada
      Pages 135-140
    7. Barry E. Ledford, Gregory H. Leno
      Pages 141-148
  5. Toxin mono-ADP-ribosylation

  6. Inhibitors and activators of ADP-ribosylation

    1. Front Matter
      Pages 183-183
    2. Marek Banasik, Kunihiro Ueda
      Pages 185-197
  7. Derivitization of Proteins with ADP-ribose, NAD and their analogues

    1. Front Matter
      Pages 199-199
    2. Lee J. McDonald, Joel Moss
      Pages 201-206
    3. Elaine L. Jacobson, Daniel Cervantes-Laurean, Myron K. Jacobson
      Pages 207-212
    4. Rafael Alvarez-Gonzalez
      Pages 213-219
    5. Lee J. McDonald, Joel Moss
      Pages 221-226
  8. Cyclic ADP-ribose, NAD hydrolysis and ADP-ribose synthesis

    1. Front Matter
      Pages 227-227
    2. Hyuntae Kim, Elaine L. Jacobson, Myron K. Jacobson
      Pages 237-243
    3. Norman J. Oppenheimer
      Pages 245-251
  9. Back Matter
    Pages 253-255

About this book


Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.


cell enzyme gene phosphorylation protein regulation synthesis translation

Editors and affiliations

  • Joel Moss
    • 1
  • Peter Zahradka
    • 2
  1. 1.Laboratory of Cellular MetabolismNational Heart, Lung and Blood Institute, NIHBethesdaUSA
  2. 2.Division of Cardiovascular SciencesSt. Boniface General Hospital Research CenterWinnipegCanada

Bibliographic information