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  • © 1994

Purine and Pyrimidine Metabolism in Man VIII

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 370)

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Table of contents (172 chapters)

  1. Front Matter

    Pages i-xxi
  2. Regulation of Purine and Pyrimidine Metabolism

    1. Clinical

      1. The Effect of Partial Hepatectomy on Blood Purine Levels in Rats and Patients
        • Makoto Usami, Koji Furuchi, Hiroshi Kasahara, Seiji Haji, George Kotani, Atsunori Iso et al.
        Pages 11-14
      2. Abnormal Purine and Pyrimidine Metabolism in Inherited Superactivity of PRPP Synthetase
        • Claude Bory, Christiane Chantin, Roselyne Boulieu
        Pages 15-18
      3. Accelerated Purine Base Salvage — A Possible Cause of Elevated Nucleotide Pool in the Erythrocytes of Patients with Uraemia
        • Maciej Marlewski, Ryszard T. Smolenski, Julian Swierczynski, Boleslaw Rutkowski, John A. Duley, H. Anne Simmonds et al.
        Pages 19-22
      4. Quantitation of TK1 mRNA in Patients with Chronic Lymphatic Leukemia
        • Tina Kristensen, Helle Kock Jensen, Birgitte Munch-Petersen
        Pages 23-26
    2. Gout

      1. Effect of Hypouricemic Agents on Serum Carbohydrate-Deficient Transferrin in Gouty Patients
        • Kiyoko Kaneko, Shin Fujimori, Hisashi Yamanaka, Ieo Akaoka
        Pages 27-30
      2. Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion
        • Yuji Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, Yumiko Nasako, Toshikazu Hada, Kazuya Higashino
        Pages 39-42
      3. <i>In Vitro</i> and <i>In Vivo</i> Study on the Conversion of Allopurinol and Pyrazinamide
        • Yumiko Nasako, Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi, Zenta Tsutsumi, Toshikazu Hada et al.
        Pages 43-46
      4. Free Oxypurines in Plasma and Urine of Gout Patients Before and After a Purine-Free Diet
        • B. Porcelli, D. Vannoni, R. Leoncini, M. Pizzichini, R. Pagani, E. Marinello
        Pages 47-52
      5. Analysis of the Genotypes for Aldehyde Dehydrogenase 2 in Japanese Patients with Primary Gout
        • Hisashi Yamanaka, Naoyuki Kamatani, Masayuki Hakoda, Chihiro Terai, Ryuji Kawaguchi, Sadao Kashiwazaki
        Pages 53-56
      6. Hypouricemia and an Increased Clearance of Uric Acid are Observed in Liver Diseases?
        • A. Pelatti, C. P. Quaratino, C. D’ Amario, R. Tentarelli, G. Riario Sforza, A. Giacomello
        Pages 57-60
      7. Purine Metabolism in Female Patients with Primary Gout
        • Juan G. Puig, Felícitas A. Mateos, Ma. E. Miranda, Rosa J. Torres, Eugenio de Miguel, Carlos Pérez de Ayala et al.
        Pages 69-72
      8. Familial Juvenile Hyperuricaemic Nephropathy in Adolescents
        • I. Sebesta, J. Krijt, K. Pavelka, J. Maly, H. A. Simmonds, M. B. McBride
        Pages 73-76
      9. Correlation of Serum Uric Acid, Cholesterol and Triglyceride Levels
        • N. Di Sciascio, C. P. Quaratino, C. Rucci, P. Ciaglia, M. N. Mariani, A. Giacomello
        Pages 77-78

About this book

These volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, Bloomington, USA from May 22- May 27, 1994. This was a continuation of meetings held every three years with the idea of bringing clinicians and basic scientists together, which we hope results in cross-fertilization of ideas. Some of the papers presented in this volume represent oral contributions and others are from posters, but we emphasize that both are considered of equal merit. As is obvious from a perusal of the titles of the papers there has been a shift in the focus of this meeting, which reflects a general shift in the area of purine and pyrimidine metabolism. The emphasis has definitely shifted to gene structure and molecular genetics, with the beginnings we hope of gene therapy as an important branch of this area of science. Although many of the inherited diseases discussed in this text can be treated with drugs, the major thrust in the futurewill be in gene therapy, where the gene (or cDNA) will be used to treat the patient with enzyme deficiency, particularly if the patient is young. As can be seen from the Iist of authors there is a remarkable degree of international cooperation in this area across countries and continents. We thank the many participants who have attended these symposia many times, and we welcome the large group of scientists from Eastern Europe who are attending this meeting for the first time.

Keywords

  • Purine
  • Pyrimidine
  • enzymes
  • gene therapy
  • metabolism

Editors and Affiliations

  • Indiana University School of Medicine, Indianapolis, USA

    Amrik Sahota

  • Indiana University, Bloomington, USA

    Milton W. Taylor

Bibliographic Information

Buying options

eBook
USD 89.00
Price excludes VAT (USA)
  • ISBN: 978-1-4615-2584-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 119.99
Price excludes VAT (USA)