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Computational Methods in Genome Research

  • Sándor Suhai

Table of contents

  1. Front Matter
    Pages i-viii
  2. Hans Lehrach, Richard Mott, Günther Zehetner
    Pages 19-24
  3. Richard Durbin, Jean Thierry-Mieg
    Pages 45-55
  4. Otto Ritter
    Pages 57-73
  5. Jacques S. Beckmann
    Pages 75-84
  6. Tom Slezak, Mark Wagner, Mimi Yeh, Roy Cantu III, Elbert Branscomb
    Pages 97-110
  7. Frank Herrmann, Sándor Suhai
    Pages 173-190
  8. M. J. Bishop, J. H. Edwards, J. L. Dicks
    Pages 209-216
  9. Back Matter
    Pages 219-227

About this book

Introduction

The application of computational methods to solve scientific and pratical problems in genome research created a new interdisciplinary area that transcends boundaries traditionally separating genetics, biology, mathematics, physics, and computer science. Computers have been, of course, intensively used for many year~ in the field of life sciences, even before genome research started, to store and analyze DNA or proteins sequences, to explore and model the three-dimensional structure, the dynamics and the function of biopolymers, to compute genetic linkage or evolutionary processes etc. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function of genomes of higher organisms, has generated, however, not only a huge and burgeoning body of data but also a new class of scientific questions. The nature and complexity of these questions will require, beyond establishing a new kind of alliance between experimental and theoretical disciplines, also the development of new generations both in computer software and hardware technologies, respectively. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can ·attack with success. Many of us still feel that computational models rationalizing experimental findings in genome research fulfil their promises more slowly than desired. There also is an uncertainity concerning the real position of a 'theoretical genome research' in the network of established disciplines integrating their efforts in this field.

Keywords

Chromosom DNA chromosome databases development evolution genetics genome mapping polymer protein proteins

Editors and affiliations

  • Sándor Suhai
    • 1
  1. 1.German Cancer Research CentreHeidelbergGermany

Bibliographic information