The Cell Cycle

Regulators, Targets, and Clinical Applications

  • Valerie W. Hu

Table of contents

  1. Front Matter
    Pages i-xi
  2. Regulators of the Cell Cycle

    1. Front Matter
      Pages 1-1
    2. Charles J. Sherr, Hitoshi Matsushime, Jun-ya Kato, Dawn E. Quelle, Martine F. Roussel
      Pages 17-23
    3. David L. Brautigan, Jian Chen, Fran Pinault, Jeremy Somers, Richard Zimmerman
      Pages 25-32
    4. Xiao-Wen Guo, John P. H. Th’ng, Richard A. Swank, E. Morton Bradbury
      Pages 41-49
    5. Luke Alphey, Helen White-Cooper, David Glover
      Pages 51-57
  3. Control of Cell Proliferation

    1. Front Matter
      Pages 59-59
    2. David J. Robbins, Erzhen Zhen, Mangeng Cheng, Colleen A. Vanderbilt, Douglas Ebert, Clark Garcia et al.
      Pages 61-66
    3. J. Carl Barrett, Cynthia A. Afshari
      Pages 79-89
    4. Joseph R. Nevins
      Pages 91-97
    5. Elias Coutavas, Mindong Ren, Joel D. Oppenheim, Vijay Yajnik, Peter D’Eustachio, Mark G. Rush
      Pages 99-110
  4. Cell Cycle Control of Gene Expression and Repair

    1. Front Matter
      Pages 121-121
    2. Franca LaBella, Rosanna Martinelli, Neil Segil, Nathaniel Heintz
      Pages 123-125
    3. Gregory S. Naeve, Li-jing Li, Lin Guo, Ajay Sharma, Amy S. Lee
      Pages 127-139
    4. Jill E. Slansky, Peggy J. Farnham
      Pages 149-154
    5. Jacqueline L. Bruce, Brendan D. Price, Stuart K. Calderwood
      Pages 155-161
    6. Stephen J. Elledge, Zheng Zhou, James B. Allen, Tony A. Navas, William J. Jones
      Pages 163-166
  5. Mitosis: Induction and Mechanics

    1. Front Matter
      Pages 173-173
    2. Laura L. Parker, Sarah A. Walter, Helen Piwnica-Worms
      Pages 175-184
    3. Annette L. Boman, Kathleen M. C. Sullivan, Katherine L. Wilson
      Pages 197-202
    4. A. Amsterdam, F. Pitzer, U. Santarius, A. Dantes, W. Baumeister
      Pages 203-209
    5. Ron Balczon, Liming Bao, Warren E. Zimmer, Kevin Brown, Raymond P. Zinkowski, B. R. Brinkley
      Pages 229-235
  6. Cell Cycle Regulation in Development

    1. Front Matter
      Pages 245-245
    2. George F. Vande Woude, Taesaeng Choi, Renping Zhou, Monica Murakami, Wayne Matten, Kenji Fukasawa
      Pages 247-249
    3. Gretchen H. Stein, Linda F. Drullinger, Emma Lees, Steven I. Reed, Vjekoslav Dulić
      Pages 251-262
    4. M. H. Lu, S. F. Ali, D. S. He, A. Turturro, R. W. Hart
      Pages 263-269
    5. David Walsh, Li Zhe, Frank Zeng, Wu Yan, Karen Li
      Pages 271-281
    6. Anat Yarden, Zvi Kam, Benjamin Geiger
      Pages 283-289
    7. L. E. Gerschenson, R. J. Rotello, R. Lieberman, C.-I. Sze
      Pages 291-299
  7. Role of the Cell Cycle in Disease

    1. Front Matter
      Pages 301-301
    2. Arthur B. Pardee, Qing-Ping Dou, Khandan Keyomarsi
      Pages 303-309
    3. Zhiqiang Zou, Anthony Anisowicz, Kristina Rafidi, Ruth Sager
      Pages 319-322
    4. Elizabeth A. Musgrove, Michael F. Buckley, Anna deFazio, Colin K. W. Watts, Robert L. Sutherland
      Pages 323-329
    5. Steven R. Patierno, Lori J. Blankenship, John P. Wise, Jian Xu, Laura C. Bridgewater, Francis C. R. Manning
      Pages 331-340
    6. Katherine K. Sanford, Ram Parshad
      Pages 341-346
    7. Toshio Nikaido, Koji Ono, Masuji Yamamoto, Toshiyuki Sakai, Yasushi Magami
      Pages 347-357
    8. Huan Tian, Dan Hartmann, Larry Wahl, Eileen Donoghue, Clare McGowan, Jeffrey Cossman et al.
      Pages 359-366
  8. Clinical Applications

    1. Front Matter
      Pages 367-367

About this book


Interest in the cell cycle has grown explosively in recent years as a result of the identification of key cell cycle regulators and their substrates. Aside from enhancing our understanding of normal cellular growth controls, this new knowledge has also becn valuable in elucidating mechanisms of growth deregulation which occur in diseased states, such as cancer and, in some instances, viral or parasitic infections. The Thirteenth Washington International Spring Symposium was organized with the intention of bringing together scientists working on different aspects of the cell cycle. Scientific topics presented ranged from molecular regulators and effectors to mitosis­ specific changes in cell architecture to the role of the cell cycle in development and disease. The goal of this gathering was to help formulate a more comprehensive and integrated picture of events driving and being driven by the cell cycle, as well as to evaluate the possibilities for clinical application of this knowledge. This symposium, held in Washington, D.C. from May 10-14, 1993, was attended by more than 400 scientists from 20 countries, including many of the scientific leaders in this field. This volume contains most of the papers presented at the seven plenary sessions in addition to selected contributions from a total of nine special oral and poster sessions.


cellular growth cyclin development gene expression regulation transcription

Editors and affiliations

  • Valerie W. Hu
    • 1
  1. 1.The George Washington University Medical CenterUSA

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