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Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

  • Ben Avi Weissman
  • Nahum Allon
  • Shlomo Shapira

Table of contents

  1. Front Matter
    Pages i-xi
  2. The Nitric Oxide Signal Transduction System

  3. Chemistry and Biochemistry of Nitric Oxide

    1. Paul L. Feldman, Dennis J. Stuehr, Owen W. Griffith, Jon M. Fukuto
      Pages 13-20
    2. Bernd Mayer
      Pages 37-48
    3. Markus Hecker, Ingrid Fleming, Kazuhide Ayajiki, Rudi Busse
      Pages 49-56
  4. Pharmacology and Drug Development

    1. Harry M. Lander, Roberto Levi, Abraham Novogrodsky
      Pages 85-91
    2. Jacques Mizrahi, Robert J. Bache, Eberhard Bassenge, Alain Berdeaux, Jean-Francois Giudicelli, Akira Ueno et al.
      Pages 93-101
    3. Karl-F. Schmidt, Gottfried N. Nöll
      Pages 103-110
    4. Aldona Dembinska-Kiec, Iwona Wybranska, Barbara Miszczuk-Jamska, Ewa Baczynska, Jadwiga Hartwich, Pawel Goldsztajn
      Pages 117-122
  5. Nitric Oxide and the Respiratory and Cardiovascular Systems

    1. Louis Diamond, Ralph J. Altiere, Greg Lindsay, David C. Thompson
      Pages 123-130
    2. David Y. Cheng, Bracken J. DeWitt, Timothy J. McMahon, Jose A. Santiago, Dennis B. McNamara, Philip J. Kadowitz
      Pages 137-144
    3. Janos G. Filep, Alain Fournier, Eva Foldes-Filep
      Pages 145-152
    4. W. Bloch, G. Dickneite, A. Krahwinkel, F. Dobers, K. Addicks
      Pages 161-165
    5. Allan M. Lefer
      Pages 167-173
    6. Dennis B. McNamara, Harmeet Aurora, Brenda Bedi, Thomas Osgood, Raphael Santiago, I-L. Chen et al.
      Pages 175-180
    7. Yaakov Ashkenazy, Valentin Witzling, Yitchak Abend, Sandra Moshonov, Uriel Zor
      Pages 181-188
  6. Nitric Oxide and Brain Functions

    1. Turgay Dalkara, Michael A. Moskowitz
      Pages 189-194
    2. Sigal Meilin, Nili Zarchin, Avraham Mayevsky, Shlomo Shapira
      Pages 195-204
    3. Gerald Wolf, Werner Schmidt, Jaroslaw Calka, Gabriele Henschke, Sabine Würdig
      Pages 213-220
    4. Shlomo Shapira, Shira Chapman, Tamar Kadar, Ben Avi Weissman, Eli Heldman
      Pages 221-230
    5. Rachel Brandeis, Michal Sapir, Eti Stein, Ben Avi Weissman
      Pages 231-238
  7. Back Matter
    Pages 245-248

About this book

Introduction

A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology­ minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e. , cyclic AMP), participate in a diverse set of functions.

Keywords

biochemistry cardiovascular system chemistry depression development drug drug development erectile dysfunction pharmacology protein receptor research smooth muscle synthesis

Editors and affiliations

  • Ben Avi Weissman
    • 1
  • Nahum Allon
    • 1
  • Shlomo Shapira
    • 1
  1. 1.Israel Institute for Biological ResearchNess-ZionaIsrael

Bibliographic information