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  • © 1995

Vaccine Design

The Subunit and Adjuvant Approach

Part of the book series: Pharmaceutical Biotechnology (PBIO, volume 6)

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  • ISBN: 978-1-4615-1823-5
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Table of contents (41 chapters)

  1. Front Matter

    Pages i-xlv
  2. Public Health Implications of Emerging Vaccine Technologies

    • Dale N. Lawrence, Karen L. Goldenthal, John W. Boslego, Donna K. F. Chandler, John R. La Montagne
    Pages 43-60
  3. Preclinical Safety Assessment Considerations in Vaccine Development

    • Jeanine L. Bussiere, George C. McCormick, James D. Green
    Pages 61-79
  4. Regulatory Considerations in Vaccine Design

    • Lawrence W. Davenport
    Pages 81-96
  5. Clinical Considerations in Vaccine Trials with Special Reference to Candidate HIV Vaccines

    • Patricia E. Fast, Leigh A. Sawyer, Susan L. Wescott
    Pages 97-134
  6. A Compendium of Vaccine Adjuvants and Excipients

    • Frederick R. Vogel, Michael F. Powell
    Pages 141-228
  7. Adjuvant Properties of Aluminum and Calcium Compounds

    • Rajesh K. Gupta, Bradford E. Rost, Edgar Relyveld, George R. Siber
    Pages 229-248
  8. Structure and Properties of Aluminum-Containing Adjuvants

    • Stanley L. Hem, Joe L. White
    Pages 249-276
  9. MF59 Design and Evaluation of a Safe and Potent Adjuvant for Human Vaccines

    • Gary Ott, Gail L. Barchfeld, David Chernoff, Ramachandran Radhakrishnan, Peter van Hoogevest, Gary Van Nest
    Pages 277-296
  10. Liposome Design and Vaccine Development

    • Patricia J. Freda Pietrobon
    Pages 347-361
  11. Lipid Matrix-Based Vaccines for Mucosal and Systemic Immunization

    • Raphael J. Mannino, Susan Gould-Fogerite
    Pages 363-387
  12. Polymer Microspheres for Vaccine Delivery

    • Justin Hanes, Masatoshi Chiba, Robert Langer
    Pages 389-412
  13. Vehicles for Oral Immunization

    • Noemi Santiago, Susan Haas, Robert A. Baughman
    Pages 413-438
  14. Nanoparticles as Adjuvants for Vaccines

    • Jörg Kreuter
    Pages 463-472

About this book

When my interest was first drawn to the phenomenon of vaccination for virus diseases in the late 1930s, the state of the art and the science of vaccine design was not far advanced beyond the time of Jenner at the end of the 18th century and of Pasteur a century later. In the 1930s it was still believed that for the induction of immunity to a virus-caused disease the experience of infection was required, but not for a toxin-caused disease such as diphtheria or tetanus, for which a chemically detoxified antigen was effective for immu­ nization. This prompted the question as to whether it might be possible to produce a similar effect for virus diseases using nonreplicating antigens. When in the 1930s and 1940s it was found possible to propagate influenza viruses in the chick embryo, protective effects could be induced without the need to experience infection by the use of a sufficient dose of a noninfectious influenza virus preparation. Later in the 1940s, it became possible to propagate polio and other viruses in cultures of human and monkey tissue and to immunize against other virus diseases in the same way. Later, with the advent of the era of molecular biology and genetic engineering, antigens and vaccines could be produced in new and creative ways, using either replicating or nonreplicating forms of the appropriate antigens for inducing a dose-related protective state.


  • antigen
  • calcium
  • protein
  • vaccine


`This book should be very valuable to anyone interested in the basic design of vaccine strategies or the preclinical evaluation of novel vaccines and adjuvants.'
Doody's Journal

`I have little doubt that this book will become a standard reference for future development of vaccine formulations.'
European Journal of Pharmaceutics and Biopharmaceutics

Editors and Affiliations

  • Genentech, Inc., South San Francisco, USA

    Michael F. Powell

  • Vaxcel, Inc., Norcross, USA

    Mark J. Newman

Bibliographic Information

  • Book Title: Vaccine Design

  • Book Subtitle: The Subunit and Adjuvant Approach

  • Editors: Michael F. Powell, Mark J. Newman

  • Series Title: Pharmaceutical Biotechnology

  • DOI:

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1995

  • Hardcover ISBN: 978-0-306-44867-6

  • eBook ISBN: 978-1-4615-1823-5

  • Series ISSN: 1078-0467

  • Edition Number: 1

  • Number of Pages: XC, 949

  • Topics: Immunology, Pharmacology, Pharmacy

Buying options

eBook USD 74.99
Price excludes VAT (USA)
  • ISBN: 978-1-4615-1823-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout