Protein Kinase CK2 — From Structure to Regulation

  • Khalil Ahmed
  • Olaf-Georg Issinger
  • Jorge E Allende

Part of the Molecular and Cellular Biochemistry book series (DMCB, volume 35)

Table of contents

  1. Front Matter
    Pages i-2
  2. Barbara Guerra, Karsten Niefind, Inessa Ermakowa, Olaf-Georg Issinger
    Pages 3-11
  3. Stefania Sarno, Paola Ghisellini, Luca Cesaro, Roberto Battistutta, Lorenzo A. Pinna
    Pages 13-19
  4. David W. Litchfield, Denis G. Bosc, David A. Canton, Ronald B. Saulnier, Greg Vilk, Cunjie Zhang
    Pages 21-29
  5. Iris Korn, Germaine Jacob, Catherine C. Allende, Jorge E. Allende
    Pages 37-44
  6. Karin Ackermann, Andrea Waxmann, Claiborne V. C. Glover, Walter Pyerin
    Pages 59-66
  7. Shihui Yu, Huamin Wang, Alan Davis, Khalil Ahmed
    Pages 67-71
  8. Michael Faust, Martin Jung, Jürgen Günther, Richard Zimmermann, Mathias Montenarh
    Pages 73-80
  9. Véronique Martel, Odile Filhol, Arsenio Nueda, Delphine Gerber, Maria Jose Benitez, Claude Cochet
    Pages 81-90
  10. Regina L. Trott, Madhavi Kalive, Umesh Karandikar, Rebecca Rummer, Clifton P. Bishop, Ashok P. Bidwai
    Pages 91-98
  11. Marco Alvarez, Gudrun Kausel, Jaime Figueroa, María Inés Vera
    Pages 107-112
  12. Marta Riera, Giovanna Peracchia, Montserrat Pagès
    Pages 119-127
  13. Paula Salinas, Brigitte Bantignies, Julio Tapia, Xavier Jordana, Loreto Holuigue
    Pages 129-135
  14. Paola Massimi, David Pim, Christian Kühne, Lawrence Banks
    Pages 137-144
  15. Flavio Meggio, Oriano Marin, Marco Boschetti, Stefania Sarno, Lorenzo A. Pinna
    Pages 145-151
  16. Esther Landesman-Bollag, Diane H. Song, Raphaelle Romieu Mourez, Daniel J. Sussman, Robert D. Cardiff, Gail E. Sonenshein et al.
    Pages 153-165

About this book

Introduction

CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation.

This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.

Keywords

enzymes mutation phosphorylation protein proteins transcription

Editors and affiliations

  • Khalil Ahmed
    • 1
  • Olaf-Georg Issinger
    • 2
  • Jorge E Allende
    • 3
  1. 1.Cellular and Molecular Biochemistry Research LabUniversity of Minnesota, Veterans Affairs Medical CenterMinneapolisUSA
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of Southern DenmarkOdenseDenmark
  3. 3.Program de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de MedicinaUniversidad de ChileCasilla, Santiago 7Chile

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1723-8
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5696-7
  • Online ISBN 978-1-4615-1723-8
  • About this book