Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

Insights for Drug Discovery

  • Tucker Collins

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Rodger P. McEver
    Pages 1-26
  3. Tucker Collins, Kelly-Ann Sheppard, Simos Simeonidis, David W. Rose
    Pages 27-53
  4. Ulrich H. von Andrian
    Pages 55-107
  5. Thomas P. Parks, Mary E. Gerritsen
    Pages 109-173
  6. Andrew Neish, Sarita Aggarwal, Tucker Collins
    Pages 175-201
  7. Frank S. Lee, Robert T. Peters, Zhijian J. Chen, Tom Maniatis
    Pages 203-227
  8. Jeffrey D. Parvin, Stephen F. Anderson
    Pages 229-261
  9. Anthony M. Manning
    Pages 303-321
  10. Back Matter
    Pages 323-327

About this book

Introduction

The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers.
This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment.
This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Keywords

cell gene expression inflammation protein proteins tissue transcription

Editors and affiliations

  • Tucker Collins
    • 1
  1. 1.Harvard Medical SchoolUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1565-4
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5617-2
  • Online ISBN 978-1-4615-1565-4
  • About this book