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Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia

Directions for the New Millennium

  • Azra Raza
  • Suneel D. Mundle

Part of the Cancer Treatment and Research book series (CTAR, volume 108)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Lambert F. R. Span, Theo M. de Witte
    Pages 45-63
  3. Gianluigi Castoldi, Gian Matteo Rigolin
    Pages 81-92
  4. Krishnan Allampallam, Vilasini T. Shetty, Azra Raza
    Pages 93-100
  5. Suneel D. Mundle
    Pages 101-109
  6. Rose Ann Padua, Angela McGlynn, Hugh McGlynn
    Pages 111-157
  7. Hans-G. Klingemann, H. Joachim Deeg
    Pages 159-168
  8. Athanasios B.-T. Fassas, Guido Tricot
    Pages 169-184
  9. Ivana Gojo, Judith E. Karp
    Pages 231-255
  10. Parameswaran Venugopal, Sharon Manson, Harvey D. Preisler
    Pages 257-265
  11. Back Matter
    Pages 279-280

About this book

Introduction

Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze this premise. Therefore, until a clearer picture of the disease emerges it is best to treat each of the MDS syndromes as a separate entity. Having no classification is better than a misleading one.
Cancer research has been notable for its periodic cycles of promise and hope, followed by defeat and disappointments. It is not that there is no solution, but that the problem has not been identified precisely. This book is our attempt to define the most crucial questions related to MDS that need to be addressed immediately through logic, analysis and rigorous experimentation. If the emerging problems appear daunting, then instead of being overwhelmed by them, we should follow the advice of the great 20th century thinker Antonio Gramsci, `pessimism of the intellect must be faced with the optimism of will'.

Keywords

aging antibiotics apoptosis cell classification cytokines hematopoietic stem cell hematopoietic stem cell transplantation leukemia stem cell stem cell transplantation transplantation

Editors and affiliations

  • Azra Raza
    • 1
  • Suneel D. Mundle
    • 1
  1. 1.MDS Center and Section of Myeloid DiseasesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1463-3
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5566-3
  • Online ISBN 978-1-4615-1463-3
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site