Biochemistry and Genetics of RecQ-Helicases

  • David B. Lombard

Table of contents

  1. Front Matter
    Pages i-1
  2. David B. Lombard
    Pages 3-19
  3. David B. Lombard
    Pages 21-41
  4. Back Matter
    Pages 77-92

About this book

Introduction

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

Keywords

DNA Mutation Nucleoside Telomere biochemistry biology cancer chemistry development enzymes genes genetics recombination transcription translation

Authors and affiliations

  • David B. Lombard
    • 1
  1. 1.Massachusetts Institute of TechnologyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1405-3
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5537-3
  • Online ISBN 978-1-4615-1405-3
  • About this book