Characterization of Compounds in Solution

Theory and Practice

  • William H. Streng

Table of contents

  1. Front Matter
    Pages i-xvii
  2. William H. Streng
    Pages 1-3
  3. William H. Streng
    Pages 5-18
  4. William H. Streng
    Pages 19-28
  5. William H. Streng
    Pages 29-46
  6. William H. Streng
    Pages 47-60
  7. William H. Streng
    Pages 61-71
  8. William H. Streng
    Pages 73-86
  9. William H. Streng
    Pages 87-97
  10. William H. Streng
    Pages 99-123
  11. William H. Streng
    Pages 125-159
  12. William H. Streng
    Pages 161-180
  13. William H. Streng
    Pages 181-218
  14. Back Matter
    Pages 271-273

About this book

Introduction

Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.

Keywords

dynamics experiment kinetics stability thermodynamics

Authors and affiliations

  • William H. Streng
    • 1
  1. 1.Quintiles, Inc.Kansas CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1345-2
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5508-3
  • Online ISBN 978-1-4615-1345-2
  • About this book