Intractable Seizures

Diagnosis, Treatment, and Prevention

  • W. McIntyre Burnham
  • Peter L. Carlen
  • Paul A. Hwang

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 497)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Intractable Epilepsy in Adults

    1. Ilo E. Leppik
      Pages 1-7
  3. Complex Partial Seizures

    1. Warren T. Blume
      Pages 9-18
    2. John P. Girvin
      Pages 27-32
  4. West’s Syndrome (Infantile Spasms)

    1. Richard A. Hrachovy
      Pages 33-50
    2. Catherine Chiron, Olivier Dulac
      Pages 51-56
    3. Harold J. Hoffman
      Pages 57-59
  5. Lennox-Gastaut Syndrome

  6. Special Topic

  7. Basic Pathophysiology—Theories and Research

    1. W. McIntyre Burnham
      Pages 107-110
    2. Harry T. Chugani
      Pages 111-121
    3. Massimo Avoli, Donatella Mattia, Andre Olivier
      Pages 123-132
  8. Effects of Unchecked Seizures—Human and Animal Studies

    1. Dietrich Blumer
      Pages 133-147
    2. Ronald J. Racine, Beth Adams, Philip Osehobo, Margaret Fahnestock
      Pages 149-170
    3. Carl E. Stafstrom, Gregory L. Holmes
      Pages 171-194
  9. New Therapeutic Strategies

    1. Hanna Kolski, Hiroshi Otsubo
      Pages 195-208
    2. Peter L. Carlen, Marc R. Pelletier, Aviv Ouanounou, Michael Tymianski, Liang Zhang
      Pages 209-224
    3. Eileen P. G. Vining
      Pages 225-231
    4. Adrian Upton
      Pages 233-239
  10. Back Matter
    Pages 241-248

About this book


About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.


children diagnosis drug drugs epilepsy growth pathophysiology physiology population prevention research surgery syndromes therapy treatment

Editors and affiliations

  • W. McIntyre Burnham
    • 1
  • Peter L. Carlen
    • 2
  • Paul A. Hwang
    • 1
  1. 1.University of TorontoTorontoCanada
  2. 2.Toronto Western Research InstituteTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5503-8
  • Online ISBN 978-1-4615-1335-3
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site